Detailed information of TA system TA098902

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1619674..1620472
• Replicon: chromosome
• Accession: NZ_CP027449
• Organism: Escherichia coli strain 2014C-3097

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1M0ZYM8
• Locus tag: C6W73_RS08320
• Protein ID: WP_000854904.1
• Coordinates: 1620095..1620472 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A093DMQ4
• Locus tag: C6W73_RS08315
• Protein ID: WP_001280952.1
• Coordinates: 1619674..1620048 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6W73_RS08270	1614825..1616002	+	1178	WP_085968792.1	IS3 family transposase	-
C6W73_RS08275	1616013..1616447	+	435	Protein_1500	hypothetical protein	-
C6W73_RS08280	1616523..1616978	+	456	WP_000581504.1	hypothetical protein	-
C6W73_RS08285	1617057..1617290	+	234	WP_001119722.1	DUF905 family protein	-
C6W73_RS08295	1617377..1618195	+	819	WP_001234620.1	DUF945 domain-containing protein	-
C6W73_RS08300	1618250..1618735	+	486	WP_000849592.1	antirestriction protein	-
C6W73_RS08305	1618751..1619227	+	477	WP_052920843.1	RadC family protein	-
C6W73_RS08310	1619290..1619511	+	222	WP_000692312.1	DUF987 domain-containing protein	-
C6W73_RS08315	1619674..1620048	+	375	WP_001280952.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C6W73_RS08320	1620095..1620472	+	378	WP_000854904.1	TA system toxin CbtA family protein	Toxin
C6W73_RS08325	1620469..1620957	+	489	WP_000779174.1	hypothetical protein	-
C6W73_RS08330	1620969..1621166	+	198	WP_000839249.1	DUF957 domain-containing protein	-
C6W73_RS08335	1621251..1622093	+	843	Protein_1511	DUF4942 domain-containing protein	-
C6W73_RS08345	1622904..1624443	+	1540	Protein_1512	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1618751..1632256	13505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-118)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14280.26 Da
• Isoelectric Point: 7.2922

>T98902 WP_000854904.1 NZ_CP027449:1620095-1620472 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T98902 NZ_CP027449:1620095-1620472 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13719.50 Da
• Isoelectric Point: 6.6249

>AT98902 WP_001280952.1 NZ_CP027449:1619674-1620048 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Nucleotide

• Length: 375 bp

>AT98902 NZ_CP027449:1619674-1620048 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A1M0ZYM8

Antitoxin

• AlphaFold DB: A0A093DMQ4