Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5200..5681 Replicon chromosome
Accession NZ_CP027449
Organism Escherichia coli strain 2014C-3097

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag C6W73_RS00060 Protein ID WP_033812095.1
Coordinates 5391..5681 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag C6W73_RS00055 Protein ID WP_033812094.1
Coordinates 5200..5391 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W73_RS27725 474..650 - 177 WP_000753060.1 hypothetical protein -
C6W73_RS00010 643..825 - 183 WP_001224672.1 hypothetical protein -
C6W73_RS00015 970..1275 - 306 WP_106884582.1 DUF4406 domain-containing protein -
C6W73_RS00020 1272..1553 - 282 WP_106884707.1 DNA-binding protein -
C6W73_RS00025 1586..2302 - 717 WP_106884583.1 DUF1627 domain-containing protein -
C6W73_RS00030 2336..2878 - 543 WP_158707421.1 replication protein -
C6W73_RS27730 2790..3821 - 1032 WP_136719337.1 phage replisome organizer -
C6W73_RS00040 3890..4315 - 426 WP_000693925.1 Rha family transcriptional regulator -
C6W73_RS00045 4299..4574 - 276 WP_047083516.1 helix-turn-helix domain-containing protein -
C6W73_RS00050 4682..5182 + 501 WP_033812093.1 helix-turn-helix transcriptional regulator -
C6W73_RS00055 5200..5391 + 192 WP_033812094.1 hypothetical protein Antitoxin
C6W73_RS00060 5391..5681 + 291 WP_033812095.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6W73_RS00065 5950..6102 + 153 WP_106884585.1 DUF1391 family protein -
C6W73_RS00070 6114..6488 + 375 WP_028985610.1 hypothetical protein -
C6W73_RS00080 7002..7190 + 189 WP_000450221.1 cell division inhibitor -
C6W73_RS00085 7187..7375 + 189 WP_000092782.1 DUF1482 family protein -
C6W73_RS00090 7468..9912 + 2445 WP_106884587.1 exonuclease -
C6W73_RS00095 9974..10243 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 970..18499 17529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11192.05 Da        Isoelectric Point: 9.9854

>T98897 WP_033812095.1 NZ_CP027449:5391-5681 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T98897 NZ_CP027449:5391-5681 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATAGTAGCCTATATTGCTAAAGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGAGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAACATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6993.76 Da        Isoelectric Point: 4.0270

>AT98897 WP_033812094.1 NZ_CP027449:5200-5391 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRSGIPHDEVMAEMENLIAQLATTNRSE

Download         Length: 192 bp

>AT98897 NZ_CP027449:5200-5391 [Escherichia coli]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACGGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAGC
CAAAGTGGCAGCAAGCCTCGCAGATCCCCGTTCTGGAATTCCGCATGATGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTACAACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References