Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 640610..641237 | Replicon | chromosome |
| Accession | NZ_CP027440 | ||
| Organism | Escherichia coli strain 2012C-4502 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2A3VZJ4 |
| Locus tag | C6W69_RS03605 | Protein ID | WP_001624509.1 |
| Coordinates | 640610..640939 (+) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | C6W69_RS03610 | Protein ID | WP_047199903.1 |
| Coordinates | 640929..641237 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6W69_RS03555 | 635973..636353 | - | 381 | WP_001204882.1 | antitermination protein | - |
| C6W69_RS03560 | 636346..636540 | - | 195 | WP_000992060.1 | protein ninH | - |
| C6W69_RS03565 | 636540..636902 | - | 363 | WP_050866487.1 | RusA family crossover junction endodeoxyribonuclease | - |
| C6W69_RS03570 | 636899..637189 | - | 291 | WP_050866488.1 | DUF1364 domain-containing protein | - |
| C6W69_RS03575 | 637213..637404 | - | 192 | WP_001254268.1 | NinE family protein | - |
| C6W69_RS03580 | 637401..637811 | - | 411 | WP_047199906.1 | recombination protein NinB | - |
| C6W69_RS03585 | 637866..638534 | - | 669 | WP_047199905.1 | ORF6N domain-containing protein | - |
| C6W69_RS03590 | 638879..639253 | + | 375 | WP_001624512.1 | DUF805 domain-containing protein | - |
| C6W69_RS03595 | 639273..639944 | - | 672 | WP_001624511.1 | hypothetical protein | - |
| C6W69_RS03600 | 639956..640381 | - | 426 | WP_106905069.1 | hypothetical protein | - |
| C6W69_RS03605 | 640610..640939 | + | 330 | WP_001624509.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C6W69_RS03610 | 640929..641237 | + | 309 | WP_047199903.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| C6W69_RS03615 | 641292..641537 | - | 246 | WP_050866385.1 | hypothetical protein | - |
| C6W69_RS03620 | 641536..642210 | + | 675 | WP_000060692.1 | DUF4145 domain-containing protein | - |
| C6W69_RS03625 | 642243..642674 | - | 432 | WP_001151119.1 | DUF977 family protein | - |
| C6W69_RS03630 | 642689..643459 | - | 771 | WP_000450880.1 | DUF1627 domain-containing protein | - |
| C6W69_RS03635 | 643485..644225 | - | 741 | Protein_678 | ATP-binding protein | - |
| C6W69_RS26460 | 644232..645233 | - | 1002 | WP_072098131.1 | DNA-binding protein | - |
| C6W69_RS03640 | 645335..645553 | - | 219 | WP_000438870.1 | hypothetical protein | - |
| C6W69_RS03645 | 645568..645864 | - | 297 | WP_000084292.1 | hypothetical protein | - |
| C6W69_RS03650 | 646008..646235 | - | 228 | WP_001068241.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stxB / stxA | 586305..656976 | 70671 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12835.93 Da Isoelectric Point: 9.9761
>T98791 WP_001624509.1 NZ_CP027440:640610-640939 [Escherichia coli]
MNYTIEYYSEEVRLEVDQLPLSMRVRYKHLIERMKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIML
HSFIKKTQKTPPAERKKAEARMKEVKHDW
MNYTIEYYSEEVRLEVDQLPLSMRVRYKHLIERMKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIML
HSFIKKTQKTPPAERKKAEARMKEVKHDW
Download Length: 330 bp
>T98791 NZ_CP027440:640610-640939 [Escherichia coli]
ATGAACTACACTATCGAATACTACAGTGAAGAGGTCCGGCTGGAAGTCGATCAGCTTCCATTGAGTATGCGTGTCCGATA
CAAACATCTCATTGAACGTATGAAGGTATACGGCAGCAATCTCGGAGAACCTCATACCAGCGCCTTTGGTGATGGGCTTT
TCGAACTCAGAATTAAAGGCAACGATGGGATTGCACGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATTATGCTG
CATAGTTTCATTAAGAAAACGCAGAAAACACCGCCAGCCGAACGCAAAAAAGCTGAAGCCAGAATGAAGGAGGTTAAGCA
TGACTGGTAA
ATGAACTACACTATCGAATACTACAGTGAAGAGGTCCGGCTGGAAGTCGATCAGCTTCCATTGAGTATGCGTGTCCGATA
CAAACATCTCATTGAACGTATGAAGGTATACGGCAGCAATCTCGGAGAACCTCATACCAGCGCCTTTGGTGATGGGCTTT
TCGAACTCAGAATTAAAGGCAACGATGGGATTGCACGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATTATGCTG
CATAGTTTCATTAAGAAAACGCAGAAAACACCGCCAGCCGAACGCAAAAAAGCTGAAGCCAGAATGAAGGAGGTTAAGCA
TGACTGGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11185.94 Da Isoelectric Point: 8.5840
>AT98791 WP_047199903.1 NZ_CP027440:640929-641237 [Escherichia coli]
MTGKRITPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
MTGKRITPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT98791 NZ_CP027440:640929-641237 [Escherichia coli]
ATGACTGGTAAACGCATTACACCTACCATGACACACGACGAAATGGCAGCCAAATGGATGGAGGATCCGGCTTTCAAAGC
AGAATACGACGCCATCGCCGACGAATTCGCACTACTTGATGAAATGCTGGCAGCACGAAAAGAAGCAGGCTTAACCCAGG
CTGAAGTTGCTGAACGTATGGGAACAAAAGCGACTGCGATCACCAGAATGGAAAGCAATCTTGCATCAGGTATAAGCGGC
CCATCATTTGCCACACTGAAAAAATTCGCCCGTGCTACAGGGAAAAAACTCCAGATCCGCTTCGTTTAA
ATGACTGGTAAACGCATTACACCTACCATGACACACGACGAAATGGCAGCCAAATGGATGGAGGATCCGGCTTTCAAAGC
AGAATACGACGCCATCGCCGACGAATTCGCACTACTTGATGAAATGCTGGCAGCACGAAAAGAAGCAGGCTTAACCCAGG
CTGAAGTTGCTGAACGTATGGGAACAAAAGCGACTGCGATCACCAGAATGGAAAGCAATCTTGCATCAGGTATAAGCGGC
CCATCATTTGCCACACTGAAAAAATTCGCCCGTGCTACAGGGAAAAAACTCCAGATCCGCTTCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|