Detailed information of TA system TA098666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1388093..1388595
• Replicon: chromosome
• Accession: NZ_CP027417
• Organism: Oligella urethralis strain FDAARGOS_329

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEQ07_RS06580
• Protein ID: WP_081941601.1
• Coordinates: 1388093..1388302 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A096A5I9
• Locus tag: CEQ07_RS06585
• Protein ID: WP_036560810.1
• Coordinates: 1388299..1388595 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ07_RS06555	1384430..1384825	-	396	WP_018026294.1	cupin domain-containing protein	-
CEQ07_RS06560	1384965..1386323	-	1359	WP_018026293.1	esterase-like activity of phytase family protein	-
CEQ07_RS06565	1386420..1386791	-	372	WP_105885943.1	hypothetical protein	-
CEQ07_RS06570	1386849..1387472	-	624	WP_018026291.1	tellurite resistance methyltransferase TehB	-
CEQ07_RS06575	1387611..1388000	+	390	WP_018026290.1	hypothetical protein	-
CEQ07_RS06580	1388093..1388302	+	210	WP_081941601.1	hypothetical protein	Toxin
CEQ07_RS06585	1388299..1388595	+	297	WP_036560810.1	putative addiction module antidote protein	Antitoxin
CEQ07_RS06595	1389406..1390341	-	936	WP_018026287.1	cation diffusion facilitator family transporter	-
CEQ07_RS06600	1390682..1391518	+	837	WP_105885432.1	class I SAM-dependent methyltransferase	-
CEQ07_RS06605	1391534..1392499	+	966	WP_048768378.1	2-hydroxyacid dehydrogenase	-
CEQ07_RS06610	1392500..1393363	-	864	WP_105885944.1	DMT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-64)

Antitoxin

• Uncharacterized protein HI1420 (6-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 8058.24 Da
• Isoelectric Point: 9.3600

>T98666 WP_081941601.1 NZ_CP027417:1388093-1388302 [Oligella urethralis]
ILQPHFGGTKYLSDGISEMRIHFGPGYRVYYAREDYVVYLLLCGGDKSSQKRDIKTAIDMWKQIQKERS

Nucleotide

• Length: 210 bp

>T98666 NZ_CP027417:1388093-1388302 [Oligella urethralis]
ATCTTACAACCTCACTTTGGAGGCACTAAGTACCTCAGTGATGGTATTTCTGAGATGCGTATTCACTTTGGACCAGGTTA
TCGGGTGTATTACGCTCGTGAAGATTACGTTGTTTACTTGCTACTGTGTGGTGGTGATAAGTCCTCTCAGAAACGTGACA
TAAAAACCGCCATCGATATGTGGAAACAAATTCAAAAGGAACGCTCATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10606.22 Da
• Isoelectric Point: 4.7719

>AT98666 WP_036560810.1 NZ_CP027417:1388299-1388595 [Oligella urethralis]
MTTIEISPYDAAEYLKSEDAIIEYLSAALDENDPALFLAALSDVARARGMTQVAKEAGIGRESLYKALAPNAKPRYDTVL
KLMTSMGIRLSIKPTTAP

Nucleotide

• Length: 297 bp

>AT98666 NZ_CP027417:1388299-1388595 [Oligella urethralis]
ATGACAACGATAGAAATTAGCCCCTACGACGCAGCAGAATATTTAAAAAGTGAGGACGCGATCATCGAATATCTTTCAGC
CGCATTAGATGAAAATGATCCGGCACTCTTCTTAGCTGCGCTTTCTGATGTCGCAAGAGCACGTGGTATGACCCAGGTTG
CTAAGGAGGCTGGTATTGGTCGTGAGAGCCTATATAAAGCCCTTGCCCCCAACGCTAAACCTCGCTATGACACCGTGCTA
AAGCTCATGACCTCAATGGGAATTCGCCTTTCCATTAAACCTACAACTGCCCCATAA

Structures

Antitoxin

• AlphaFold DB: A0A096A5I9