Detailed information of TA system TA098660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 86594..87119
• Replicon: plasmid unnamed2
• Accession: NZ_CP027413
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain FDAARGOS_320

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: CEP98_RS00550
• Protein ID: WP_001159863.1
• Coordinates: 86594..86899 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: CEP98_RS00555
• Protein ID: WP_000813641.1
• Coordinates: 86901..87119 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP98_RS00510	81973..82533	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
CEP98_RS26230	82689..82976	+	288	WP_071530243.1	hypothetical protein	-
CEP98_RS00515	83253..83738	-	486	WP_000905606.1	membrane protein	-
CEP98_RS00520	83732..84241	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
CEP98_RS00530	84245..84958	-	714	Protein_99	EAL domain-containing protein	-
CEP98_RS00535	84967..85749	-	783	WP_000082169.1	site-specific integrase	-
CEP98_RS00540	85784..86305	-	522	WP_000198608.1	hypothetical protein	-
CEP98_RS00545	86302..86592	-	291	WP_001266176.1	hypothetical protein	-
CEP98_RS00550	86594..86899	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
CEP98_RS00555	86901..87119	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CEP98_RS00560	87795..88316	+	522	WP_010999942.1	hypothetical protein	-
CEP98_RS00570	88800..89096	+	297	WP_001687482.1	hypothetical protein	-
CEP98_RS00575	89590..90579	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
CEP98_RS00580	90838..91282	-	445	Protein_108	site-specific integrase	-
CEP98_RS00585	91451..91832	-	382	Protein_109	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93832	93832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T98660 WP_001159863.1 NZ_CP027413:c86899-86594 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T98660 NZ_CP027413:c86899-86594 [Salmonella enterica subsp. enterica serovar Typhimurium]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT98660 WP_000813641.1 NZ_CP027413:c87119-86901 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT98660 NZ_CP027413:c87119-86901 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6