Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 4023182..4023887 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CEQ36_RS18845 Protein ID WP_080608089.1
Coordinates 4023182..4023553 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CEQ36_RS18850 Protein ID WP_080608090.1
Coordinates 4023555..4023887 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS18805 4018427..4018918 + 492 WP_192945362.1 hypothetical protein -
CEQ36_RS18810 4019058..4019324 + 267 WP_080608082.1 hypothetical protein -
CEQ36_RS18815 4019823..4020644 + 822 WP_080608083.1 DUF945 domain-containing protein -
CEQ36_RS18820 4020644..4020907 + 264 WP_080608084.1 hypothetical protein -
CEQ36_RS18825 4021036..4021467 + 432 WP_080608085.1 antirestriction protein -
CEQ36_RS18830 4021487..4021972 + 486 WP_080608086.1 DNA repair protein RadC -
CEQ36_RS18835 4021998..4022786 + 789 WP_080608087.1 hypothetical protein -
CEQ36_RS18840 4022800..4023126 + 327 WP_080608088.1 hypothetical protein -
CEQ36_RS18845 4023182..4023553 + 372 WP_080608089.1 TA system toxin CbtA family protein Toxin
CEQ36_RS18850 4023555..4023887 + 333 WP_080608090.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEQ36_RS18855 4023972..4024832 + 861 WP_080608091.1 DUF4942 domain-containing protein -
CEQ36_RS18860 4025129..4025689 + 561 WP_050536341.1 hypothetical protein -
CEQ36_RS18865 4026006..4026863 - 858 WP_080608092.1 hypothetical protein -
CEQ36_RS18870 4026856..4028406 - 1551 WP_080608093.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(14-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13707.75 Da        Isoelectric Point: 8.4254

>T98645 WP_080608089.1 NZ_CP027397:4023182-4023553 [Yersinia intermedia]
MKPRPTPPGALTVPVIYQQLLAFLLEHYYGLSLNDTPYHDEQVIAQQIEREISVGDTVNALVEKYALVRIGRAGFSALAQ
DTTLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIQPQRKI

Download         Length: 372 bp

>T98645 NZ_CP027397:4023182-4023553 [Yersinia intermedia]
ATGAAACCACGTCCCACCCCACCGGGCGCATTGACCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTCCTGCTGGAGCA
TTACTACGGCCTGAGCCTCAACGATACGCCTTATCACGATGAACAGGTGATTGCGCAACAGATTGAGCGGGAGATTTCAG
TGGGTGATACCGTCAATGCTCTGGTTGAAAAATATGCTCTGGTGCGTATCGGCCGTGCCGGGTTCAGTGCATTGGCGCAA
GACACCACGCTGAGCAAGGGAGATATCGCCCGAGCACGCCAGGCTGCGGGGCTGTGGCGAGCACATTTTCCGCCCACCTT
GCTCTACCCAACCGAGTCCCTCAACCCTATTCAACCACAGAGAAAAATTTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12030.63 Da        Isoelectric Point: 6.3159

>AT98645 WP_080608090.1 NZ_CP027397:4023555-4023887 [Yersinia intermedia]
MDNNITTAPAWGLQCDITPRLGARLVQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPALITKLESQLLSGALDPRRQQG
ITVRHGEWVCDADTLGSHGYVYISVYQKLA

Download         Length: 333 bp

>AT98645 NZ_CP027397:4023555-4023887 [Yersinia intermedia]
ATGGATAACAACATTACCACCGCCCCGGCATGGGGCCTGCAATGTGATATTACACCACGGTTGGGAGCCCGATTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAACTGCTGTCCGGTGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGAGAATGGGTCTGTGACGCGGATACGCTGGGCAGTCACGGTTATGTCTATATCTCGGTATATCA
GAAACTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References