Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2741505..2742185 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CEQ36_RS12980 Protein ID WP_080607979.1
Coordinates 2741505..2741825 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CEQ36_RS12985 Protein ID WP_080607980.1
Coordinates 2741862..2742185 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS12965 2738329..2740167 + 1839 WP_005190373.1 RNA polymerase sigma factor RpoD -
CEQ36_RS12975 2740557..2741390 - 834 WP_080607978.1 DUF4942 domain-containing protein -
CEQ36_RS12980 2741505..2741825 - 321 WP_080607979.1 TA system toxin CbtA family protein Toxin
CEQ36_RS12985 2741862..2742185 - 324 WP_080607980.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEQ36_RS12990 2742198..2742671 - 474 WP_080607981.1 DNA repair protein RadC -
CEQ36_RS12995 2742742..2743563 - 822 WP_080607982.1 DUF945 domain-containing protein -
CEQ36_RS13000 2743683..2744135 - 453 WP_080608450.1 hypothetical protein -
CEQ36_RS13005 2744261..2744893 - 633 WP_080607983.1 hypothetical protein -
CEQ36_RS13010 2744899..2745600 - 702 WP_080607984.1 transcriptional regulator -
CEQ36_RS13015 2745813..2746688 - 876 WP_080607985.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12145.79 Da        Isoelectric Point: 5.9637

>T98643 WP_080607979.1 NZ_CP027397:c2741825-2741505 [Yersinia intermedia]
MHISSVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHNDAAIEEHIEAEIKLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

>T98643 NZ_CP027397:c2741825-2741505 [Yersinia intermedia]
ATGCACATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTTTTAGAACACCATTATGGCCTCACGCTCAACGACACGCCATTCCATAACGACGCGGCCATTGAGGAGCATATCG
AAGCGGAAATAAAGCTTGCCGATGCGGTTAATTTCCTGGTGGAACGCTATGAACTGGTGCGCACTGATCGTAAGGGTTTC
ACCTGGCAGGAGCAGACACCATTTCTGACTGCTACCGATATTCTCAGAGCAAGACGTGCTACCGGGCTGATGAATACGTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11945.44 Da        Isoelectric Point: 5.8657

>AT98643 WP_080607980.1 NZ_CP027397:c2742185-2741862 [Yersinia intermedia]
MPLTQSHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFTPAQLQSLEQAFPLLIVQLENMLHSGELNPHHQHQVA
VQLAEFTSIADTRGSCGYVYISIYPTE

Download         Length: 324 bp

>AT98643 NZ_CP027397:c2742185-2741862 [Yersinia intermedia]
ATGCCATTAACACAATCCCATGAATGGGGGTTGCAAAGCGATATCACCCCACGATTTGGCGCAAGATTGGTTCAGGAAGG
TAACCGGCTGCATTACCTGGCTGACAGGGCCGGTTTGACGGGGAGCTTTACACCAGCGCAGTTACAGAGTTTGGAGCAGG
CTTTCCCGCTGTTGATAGTACAACTGGAAAATATGCTGCATTCCGGTGAGCTAAATCCACATCATCAACATCAGGTGGCA
GTTCAACTTGCTGAATTCACCAGCATAGCGGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAACCGA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References