Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2407000..2407675 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name cptA Uniprot ID A0A0T9MA63
Locus tag CEQ36_RS11425 Protein ID WP_032908006.1
Coordinates 2407000..2407428 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9M975
Locus tag CEQ36_RS11430 Protein ID WP_005193092.1
Coordinates 2407409..2407675 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS11405 2402785..2403303 + 519 WP_042569196.1 flavodoxin FldB -
CEQ36_RS11410 2403354..2404760 - 1407 WP_005185995.1 cell envelope integrity protein CreD -
CEQ36_RS11415 2404853..2406280 - 1428 WP_050089078.1 two-component system sensor histidine kinase CreC -
CEQ36_RS11420 2406308..2407003 - 696 WP_032908003.1 two-component system response regulator CreB -
CEQ36_RS11425 2407000..2407428 - 429 WP_032908006.1 protein YgfX Toxin
CEQ36_RS11430 2407409..2407675 - 267 WP_005193092.1 FAD assembly factor SdhE Antitoxin
CEQ36_RS11435 2408041..2409033 + 993 WP_050297300.1 tRNA-modifying protein YgfZ -
CEQ36_RS11440 2409091..2409741 - 651 WP_005193099.1 hemolysin III family protein -
CEQ36_RS11445 2410096..2410704 + 609 WP_050297299.1 HD domain-containing protein -
CEQ36_RS11450 2410766..2411515 - 750 WP_005193105.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16529.42 Da        Isoelectric Point: 10.3815

>T98641 WP_032908006.1 NZ_CP027397:c2407428-2407000 [Yersinia intermedia]
VAQWRCDLRVSWHTQLFSLLSHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNLVLWKRL
EWIVVKQPWITRYGVLLNLQQSSSRSARKRLWLAADSMSEDEWRQLCLLLRHSFGSDKGMNQ

Download         Length: 429 bp

>T98641 NZ_CP027397:c2407428-2407000 [Yersinia intermedia]
GTGGCCCAGTGGCGATGTGACTTGCGGGTATCCTGGCACACTCAACTCTTCTCTTTATTGTCTCATGGTGTTTTGGTCAT
ACTCACCTTGGTTGCACCCTGGCCCCAGGGGTATACCGCACTGTGGTTGGTATTGCTGACGCTGGTAGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCCTGTCAAGGCGAGATCCGGCTGAAACCCGGTAACCTGGTTCTATGGAAAAGGCTC
GAATGGATCGTGGTCAAACAGCCATGGATCACCCGTTATGGCGTGTTATTAAATCTACAGCAGTCGAGCAGCCGTTCAGC
CCGTAAGCGGTTGTGGCTGGCCGCCGACAGTATGTCAGAAGATGAGTGGCGGCAATTATGTCTGCTATTGCGGCATTCAT
TTGGCTCAGATAAAGGTATGAATCAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10462.96 Da        Isoelectric Point: 5.1405

>AT98641 WP_005193092.1 NZ_CP027397:c2407675-2407409 [Yersinia intermedia]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT98641 NZ_CP027397:c2407675-2407409 [Yersinia intermedia]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGTGGTATGCGTGAACTTGATATCTCTATCATGCCGTT
TTTTGAACATGAGTATGATGGCTTGAGTGATAACGAGAAGCAGGCATTTATTCGCTTACTTGAGTGTGATGACCCAGACT
TATTCAATTGGCTGATGAATCACGGGGAGCCGCAGGACAGCGAACTGCGCCAGATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9MA63

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M975

References