Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1604758..1605593 Replicon chromosome
Accession NZ_CP027352
Organism Escherichia coli strain 2012C-4606

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag AYN42_RS09510 Protein ID WP_000854757.1
Coordinates 1605216..1605593 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag AYN42_RS09505 Protein ID WP_001295723.1
Coordinates 1604758..1605126 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYN42_RS09460 1600866..1601213 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
AYN42_RS09465 1601210..1601614 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
AYN42_RS09470 1601703..1602044 + 342 WP_072097794.1 hypothetical protein -
AYN42_RS09475 1602123..1602356 + 234 WP_001119729.1 DUF905 family protein -
AYN42_RS09485 1602456..1603273 + 818 Protein_1731 DUF932 domain-containing protein -
AYN42_RS09490 1603328..1603813 + 486 WP_000849582.1 antirestriction protein -
AYN42_RS09495 1603829..1604305 + 477 WP_001186725.1 RadC family protein -
AYN42_RS09500 1604374..1604595 + 222 WP_000692323.1 DUF987 domain-containing protein -
AYN42_RS09505 1604758..1605126 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AYN42_RS09510 1605216..1605593 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
AYN42_RS09515 1605590..1605793 + 204 WP_000761705.1 hypothetical protein -
AYN42_RS31580 1605806..1605919 + 114 WP_001161660.1 DUF957 domain-containing protein -
AYN42_RS31585 1606735..1607106 + 372 WP_001295631.1 IS110 family transposase -
AYN42_RS09535 1607560..1607742 + 183 WP_024167529.1 ethanolamine utilization protein -
AYN42_RS09540 1607843..1608172 - 330 WP_000450409.1 DUF496 family protein -
AYN42_RS09545 1608344..1609402 - 1059 WP_001200887.1 FUSC family protein -
AYN42_RS09550 1609600..1610073 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T98232 WP_000854757.1 NZ_CP027352:1605216-1605593 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T98232 NZ_CP027352:1605216-1605593 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT98232 WP_001295723.1 NZ_CP027352:1604758-1605126 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT98232 NZ_CP027352:1604758-1605126 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References