Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3065132..3065969 Replicon chromosome
Accession NZ_CP027331
Organism Escherichia coli strain 2013C-3277

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U9LL67
Locus tag MJ63_RS16760 Protein ID WP_000854687.1
Coordinates 3065132..3065512 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LJJ3
Locus tag MJ63_RS16765 Protein ID WP_001443392.1
Coordinates 3065601..3065969 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ63_RS16730 3060775..3062616 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
MJ63_RS16735 3062695..3063201 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
MJ63_RS16745 3063501..3064345 - 845 Protein_3071 DUF4942 domain-containing protein -
MJ63_RS16750 3064430..3064627 - 198 WP_000772026.1 DUF957 domain-containing protein -
MJ63_RS16755 3064647..3065135 - 489 WP_001054228.1 hypothetical protein -
MJ63_RS16760 3065132..3065512 - 381 WP_000854687.1 TA system toxin CbtA family protein Toxin
MJ63_RS16765 3065601..3065969 - 369 WP_001443392.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ63_RS16770 3066045..3066266 - 222 WP_000692312.1 DUF987 domain-containing protein -
MJ63_RS16775 3066329..3066805 - 477 WP_001186728.1 RadC family protein -
MJ63_RS16780 3066821..3067294 - 474 WP_001444656.1 antirestriction protein -
MJ63_RS16785 3067388..3067633 - 246 WP_000680587.1 hypothetical protein -
MJ63_RS16790 3067633..3068073 - 441 Protein_3080 DUF932 domain-containing protein -
MJ63_RS16800 3068452..3069608 + 1157 WP_100699673.1 IS3-like element IS600 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14199.13 Da        Isoelectric Point: 6.8615

>T98040 WP_000854687.1 NZ_CP027331:c3065512-3065132 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNNITLGRHPEEAKQ

Download         Length: 381 bp

>T98040 NZ_CP027331:c3065512-3065132 [Escherichia coli]
ATGAAAACATTACCCGACACTCACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCTCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATCCTCCGGGCCCGCAGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13781.54 Da        Isoelectric Point: 6.2049

>AT98040 WP_001443392.1 NZ_CP027331:c3065969-3065601 [Escherichia coli]
VSDTLHETNYPNDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLDDRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVALYAKGLTCDADTLGSCGYVYLAVYPTPDMKK

Download         Length: 369 bp

>AT98040 NZ_CP027331:c3065969-3065601 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAAATTATCCCAACGACAATCACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGACGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTAGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGGCACTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGATATGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LL67

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LJJ3

References