Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3261557..3262355 Replicon chromosome
Accession NZ_CP027323
Organism Escherichia coli strain 2013C-3033

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0P7PH46
Locus tag C6N24_RS17375 Protein ID WP_000854896.1
Coordinates 3261978..3262355 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A234XUW5
Locus tag C6N24_RS17370 Protein ID WP_024175300.1
Coordinates 3261557..3261931 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N24_RS17345 3258901..3259134 + 234 WP_001117568.1 DUF905 family protein -
C6N24_RS17350 3259225..3260043 + 819 WP_033884686.1 DUF945 domain-containing protein -
C6N24_RS17355 3260133..3260618 + 486 WP_000214386.1 antirestriction protein -
C6N24_RS17360 3260634..3261110 + 477 WP_001186727.1 RadC family protein -
C6N24_RS17365 3261173..3261394 + 222 WP_000692358.1 DUF987 domain-containing protein -
C6N24_RS17370 3261557..3261931 + 375 WP_024175300.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6N24_RS17375 3261978..3262355 + 378 WP_000854896.1 TA system toxin CbtA family protein Toxin
C6N24_RS17380 3262352..3262840 + 489 WP_000761662.1 hypothetical protein -
C6N24_RS17385 3262852..3263049 + 198 WP_000839256.1 DUF957 domain-containing protein -
C6N24_RS17390 3263134..3264000 + 867 WP_000014510.1 DUF4942 domain-containing protein -
C6N24_RS17395 3264072..3264335 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
C6N24_RS17400 3264332..3264658 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
C6N24_RS17410 3265072..3265608 - 537 WP_000942798.1 GspM family type II secretion system protein YghD -
C6N24_RS17415 3265610..3266788 - 1179 WP_000094987.1 type II secretion system protein GspL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3224791..3264658 39867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14210.19 Da        Isoelectric Point: 7.2920

>T97973 WP_000854896.1 NZ_CP027323:3261978-3262355 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T97973 NZ_CP027323:3261978-3262355 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13664.42 Da        Isoelectric Point: 6.4757

>AT97973 WP_024175300.1 NZ_CP027323:3261557-3261931 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Download         Length: 375 bp

>AT97973 NZ_CP027323:3261557-3261931 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAA
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGCGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATTCCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCAACCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7PH46

Antitoxin

Source ID Structure
AlphaFold DB A0A234XUW5

References