Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 192529..193268 Replicon chromosome
Accession NZ_CP027225
Organism Phytobacter sp. SCO41

Toxin (Protein)


Gene name tacT Uniprot ID A0A348D6L8
Locus tag C5523_RS00925 Protein ID WP_039080181.1
Coordinates 192783..193268 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A348D6L7
Locus tag C5523_RS00920 Protein ID WP_039080180.1
Coordinates 192529..192795 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5523_RS00900 188602..188907 + 306 WP_172960866.1 YsaB family lipoprotein -
C5523_RS00905 189013..189924 + 912 WP_004126458.1 glycine--tRNA ligase subunit alpha -
C5523_RS00910 189934..192003 + 2070 WP_039080179.1 glycine--tRNA ligase subunit beta -
C5523_RS00915 192123..192371 + 249 Protein_177 IS30 family transposase -
C5523_RS00920 192529..192795 + 267 WP_039080180.1 DUF1778 domain-containing protein Antitoxin
C5523_RS00925 192783..193268 + 486 WP_039080181.1 GNAT family N-acetyltransferase Toxin
C5523_RS00930 193854..195473 + 1620 WP_108700466.1 ATP-binding cassette domain-containing protein -
C5523_RS00935 195517..195810 - 294 WP_039080183.1 HTH-type transcriptional regulator -
C5523_RS00940 196188..196898 + 711 WP_039080184.1 DUF3053 domain-containing protein -
C5523_RS00945 196968..197942 - 975 WP_071195041.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17775.56 Da        Isoelectric Point: 10.2934

>T97704 WP_039080181.1 NZ_CP027225:192783-193268 [Phytobacter sp. SCO41]
VGRVTAPEPLSNFHQVAAFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKKDTKQIVGFYSLATGSVNHTETTGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T97704 NZ_CP027225:192783-193268 [Phytobacter sp. SCO41]
GTGGGACGTGTAACAGCGCCAGAGCCTTTATCCAATTTCCATCAGGTGGCGGCGTTTGTTAGCGGTGAAGCTGTGCTCGA
TGATTGGCTAAAGCAGAGAGGCCTCAAAAATCAGGCTCTCGGAGCTGCCCGAACTTTTGTTGTATGTAAGAAAGACACGA
AACAAATAGTCGGTTTTTACTCTTTGGCCACCGGTAGCGTCAACCATACAGAAACTACAGGCAACCTTCGGCGTAACATG
CCAGACCCTATTCCTGTGATTATACTCGCCCGGCTTGCTGTCGACGTCTCATTTCGTGGAAAAGGGCTTGGCGCTGATTT
ACTCCACGATGCGGTGCTTCGTTGTTATCGAGTTGCTGAAAATATTGGTGTGCGTGCAATCATGGTTCACGCGCTGACGG
AAGAAGCCAAAAATTTCTATATTCACCATGGTTTCAAGCCATCACAAACTCAGCAGCGGACGTTATTCCTTAAACTTCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT97704 WP_039080180.1 NZ_CP027225:192529-192795 [Phytobacter sp. SCO41]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILERRAFNFNDEQYAEFIDMLDAPVADDPVIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT97704 NZ_CP027225:192529-192795 [Phytobacter sp. SCO41]
ATGAAATCAGATGTTCAACTTAACCTTAGAGCCAAGGAATCACAGCGAGCACTCATTGATGCCGCCGCTGAGATCCTGCA
CAAATCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCTGAAAATGTGATTCTTGAGCGACGTGCCTTTAATT
TTAACGATGAGCAATATGCAGAGTTCATCGATATGCTCGATGCACCGGTTGCGGATGATCCCGTTATCGACAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348D6L8

Antitoxin

Source ID Structure
AlphaFold DB A0A348D6L7

References