Detailed information of TA system TA097588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 14916..15567
• Replicon: plasmid unnamed4
• Accession: NZ_CP027186
• Organism: Acinetobacter baumannii strain AR_0052

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N8YFZ1
• Locus tag: CSB68_RS21070
• Protein ID: WP_000269904.1
• Coordinates: 15211..15567 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CSB68_RS21065
• Protein ID: WP_001129974.1
• Coordinates: 14916..15218 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB68_RS21020	10458..11219	+	762	WP_000425105.1	hypothetical protein	-
CSB68_RS21025	11366..11797	-	432	WP_000042163.1	MarR family transcriptional regulator	-
CSB68_RS21030	11804..12232	-	429	WP_000105988.1	organic hydroperoxide resistance protein	-
CSB68_RS21035	12804..13076	-	273	WP_000369782.1	helix-turn-helix domain-containing protein	-
CSB68_RS21040	13069..13389	-	321	WP_000897309.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CSB68_RS21045	13576..13773	-	198	WP_000476222.1	hypothetical protein	-
CSB68_RS21050	13840..14067	-	228	WP_000921865.1	hypothetical protein	-
CSB68_RS21055	14165..14380	-	216	WP_000071892.1	cold-shock protein	-
CSB68_RS21060	14714..14923	-	210	WP_000069474.1	hypothetical protein	-
CSB68_RS21065	14916..15218	-	303	WP_001129974.1	XRE family transcriptional regulator	Antitoxin
CSB68_RS21070	15211..15567	-	357	WP_000269904.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CSB68_RS21075	16186..16614	+	429	WP_000105988.1	organic hydroperoxide resistance protein	-
CSB68_RS21080	16621..17052	+	432	WP_000042163.1	MarR family transcriptional regulator	-
CSB68_RS21085	17199..17960	-	762	WP_000425105.1	hypothetical protein	-
CSB68_RS21090	18265..19434	+	1170	WP_002134206.1	MobA/MobL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..38505	38505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-81)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13488.42 Da
• Isoelectric Point: 5.7104

>T97588 WP_000269904.1 NZ_CP027186:c15567-15211 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T97588 NZ_CP027186:c15567-15211 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11150.97 Da
• Isoelectric Point: 7.3198

>AT97588 WP_001129974.1 NZ_CP027186:c15218-14916 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT97588 NZ_CP027186:c15218-14916 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: N8YFZ1