Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 26191..26716 Replicon plasmid unnamed2
Accession NZ_CP027184
Organism Acinetobacter baumannii strain AR_0052

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Y3F8
Locus tag CSB68_RS20130 Protein ID WP_000221350.1
Coordinates 26191..26478 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R9B9T8
Locus tag CSB68_RS20135 Protein ID WP_000192612.1
Coordinates 26468..26716 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB68_RS20105 22048..22350 + 303 Protein_21 IS1-like element ISAba3 family transposase -
CSB68_RS20110 22534..22947 + 414 WP_005020944.1 hypothetical protein -
CSB68_RS20115 22950..23264 + 315 WP_000723215.1 hypothetical protein -
CSB68_RS20120 23466..24032 - 567 WP_000678311.1 recombinase family protein -
CSB68_RS20125 24669..25919 - 1251 Protein_25 IS3 family transposase -
CSB68_RS20130 26191..26478 - 288 WP_000221350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB68_RS20135 26468..26716 - 249 WP_000192612.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSB68_RS20140 26719..27144 - 426 WP_001083446.1 hypothetical protein -
CSB68_RS20145 27227..27295 - 69 Protein_29 helix-turn-helix domain-containing protein -
CSB68_RS20150 27411..27647 - 237 WP_000592589.1 hypothetical protein -
CSB68_RS20155 27644..28273 - 630 WP_000584713.1 AAA family ATPase -
CSB68_RS20160 28698..29645 + 948 WP_000845976.1 replication initiation protein RepM -
CSB68_RS20165 29850..30188 - 339 Protein_33 DUF3387 domain-containing protein -
CSB68_RS20170 30183..30377 + 195 Protein_34 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..60699 60699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11054.85 Da        Isoelectric Point: 10.0443

>T97583 WP_000221350.1 NZ_CP027184:c26478-26191 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPHIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T97583 NZ_CP027184:c26478-26191 [Acinetobacter baumannii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCACATTCCCAAGAATAAGCTCTCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTGTTGTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9246.72 Da        Isoelectric Point: 5.0491

>AT97583 WP_000192612.1 NZ_CP027184:c26716-26468 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT97583 NZ_CP027184:c26716-26468 [Acinetobacter baumannii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Y3F8

Antitoxin

Source ID Structure
AlphaFold DB R9B9T8

References