Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3728133..3728353 Replicon chromosome
Accession NZ_CP027027
Organism Shigella dysenteriae strain E670/74

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag C5S64_RS20355 Protein ID WP_000170955.1
Coordinates 3728246..3728353 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3728133..3728199 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5S64_RS20330 3723411..3724805 - 1395 WP_000086192.1 inverse autotransporter invasin YchO -
C5S64_RS20335 3724991..3725344 + 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
C5S64_RS20340 3725388..3726083 - 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
C5S64_RS20345 3726241..3726471 - 231 WP_105241993.1 putative cation transport regulator ChaB -
C5S64_RS20350 3726741..3727841 + 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
- 3728133..3728199 - 67 - - Antitoxin
C5S64_RS20355 3728246..3728353 + 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
C5S64_RS20360 3728502..3729356 - 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
C5S64_RS20365 3729392..3730201 - 810 WP_001257048.1 invasion regulator SirB1 -
C5S64_RS20370 3730205..3730597 - 393 WP_000200378.1 invasion regulator SirB2 -
C5S64_RS20375 3730594..3731427 - 834 WP_000386244.1 peptide chain release factor N(5)-glutamine methyltransferase -
C5S64_RS20380 3731427..3732509 - 1083 WP_000804726.1 peptide chain release factor 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T97034 WP_000170955.1 NZ_CP027027:3728246-3728353 [Shigella dysenteriae]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T97034 NZ_CP027027:3728246-3728353 [Shigella dysenteriae]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT97034 NZ_CP027027:c3728199-3728133 [Shigella dysenteriae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References