Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 562973..563157 Replicon chromosome
Accession NZ_CP026961
Organism Staphylococcus aureus strain FDAARGOS_10

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag RK68_RS03340 Protein ID WP_000482650.1
Coordinates 563050..563157 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 562973..563033 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK68_RS03315 558503..558670 - 168 WP_001790576.1 hypothetical protein -
RK68_RS03325 558901..560634 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
RK68_RS03330 560659..562422 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 562973..563033 + 61 - - Antitoxin
RK68_RS03340 563050..563157 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
RK68_RS03345 563291..563677 - 387 WP_000779358.1 flippase GtxA -
RK68_RS03350 563945..565087 + 1143 WP_001176863.1 glycerate kinase -
RK68_RS03355 565147..565806 + 660 WP_000831298.1 membrane protein -
RK68_RS03360 565988..567199 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
RK68_RS03365 567322..567795 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T96855 WP_000482650.1 NZ_CP026961:c563157-563050 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T96855 NZ_CP026961:c563157-563050 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT96855 NZ_CP026961:562973-563033 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References