Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 858051..858886 Replicon chromosome
Accession NZ_CP026935
Organism Escherichia coli strain CFS3292

Toxin (Protein)


Gene name yeeV Uniprot ID F4TIK8
Locus tag C5F72_RS04190 Protein ID WP_000854694.1
Coordinates 858051..858428 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TIK7
Locus tag C5F72_RS04195 Protein ID WP_001285605.1
Coordinates 858518..858886 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5F72_RS04155 853132..853731 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
C5F72_RS04160 853734..854711 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
C5F72_RS04165 854708..855886 + 1179 WP_000094991.1 type II secretion system protein GspL -
C5F72_RS04170 855888..856424 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
C5F72_RS04175 856705..857547 - 843 WP_021572009.1 DUF4942 domain-containing protein -
C5F72_RS04180 857632..857829 - 198 WP_086795284.1 DUF957 domain-containing protein -
C5F72_RS04185 857905..858054 - 150 Protein_824 hypothetical protein -
C5F72_RS04190 858051..858428 - 378 WP_000854694.1 TA system toxin CbtA family protein Toxin
C5F72_RS04195 858518..858886 - 369 WP_001285605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C5F72_RS04200 858966..859187 - 222 WP_000692309.1 DUF987 domain-containing protein -
C5F72_RS04205 859250..859726 - 477 WP_001366855.1 RadC family protein -
C5F72_RS04210 859742..860221 - 480 WP_000844100.1 antirestriction protein -
C5F72_RS04215 860303..861121 - 819 WP_001175148.1 DUF945 domain-containing protein -
C5F72_RS04220 861211..861444 - 234 WP_001278287.1 DUF905 family protein -
C5F72_RS04225 861450..862127 - 678 WP_001097302.1 hypothetical protein -
C5F72_RS04230 862275..862955 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14008.02 Da        Isoelectric Point: 7.7293

>T96704 WP_000854694.1 NZ_CP026935:c858428-858051 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T96704 NZ_CP026935:c858428-858051 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.48 Da        Isoelectric Point: 6.0601

>AT96704 WP_001285605.1 NZ_CP026935:c858886-858518 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT96704 NZ_CP026935:c858886-858518 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCTGTATTAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2F934

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2V3N6

References