Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 104999..105738 Replicon plasmid unnamed1
Accession NZ_CP026851
Organism Enterobacter cloacae complex sp. strain AR_0072

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag AM451_RS23500 Protein ID WP_045358131.1
Coordinates 105253..105738 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag AM451_RS23495 Protein ID WP_007869691.1
Coordinates 104999..105265 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM451_RS23470 (AM451_23475) 100554..101324 + 771 WP_032670855.1 TraX family protein -
AM451_RS23475 (AM451_23480) 101339..101662 + 324 WP_015572034.1 hypothetical protein -
AM451_RS23480 (AM451_23485) 101640..102443 - 804 WP_032670854.1 DUF4225 domain-containing protein -
AM451_RS23485 (AM451_23490) 103333..104346 - 1014 WP_032670853.1 plasmid replication initiator RepA -
AM451_RS23495 (AM451_23500) 104999..105265 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
AM451_RS23500 (AM451_23505) 105253..105738 + 486 WP_045358131.1 GNAT family N-acetyltransferase Toxin
AM451_RS23505 (AM451_23510) 105945..107290 + 1346 Protein_116 ISNCY family transposase -
AM451_RS24600 107459..107590 + 132 WP_255409921.1 hypothetical protein -
AM451_RS23510 (AM451_23515) 107803..109141 - 1339 Protein_118 IS3 family transposase -
AM451_RS23520 (AM451_23525) 110581..110697 - 117 Protein_120 transposase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..150426 150426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17752.45 Da        Isoelectric Point: 9.5181

>T96474 WP_045358131.1 NZ_CP026851:105253-105738 [Enterobacter cloacae complex sp.]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGASRTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T96474 NZ_CP026851:105253-105738 [Enterobacter cloacae complex sp.]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCATCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT96474 WP_007869691.1 NZ_CP026851:104999-105265 [Enterobacter cloacae complex sp.]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT96474 NZ_CP026851:104999-105265 [Enterobacter cloacae complex sp.]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References