Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2733462..2734100 Replicon chromosome
Accession NZ_CP026846
Organism Shigella boydii strain 59-2708

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C1P57_RS13825 Protein ID WP_078166743.1
Coordinates 2733924..2734100 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C1P57_RS13820 Protein ID WP_001270286.1
Coordinates 2733462..2733878 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P57_RS13805 (2729149) 2729149..2730294 - 1146 WP_078166744.1 ABC transporter substrate-binding protein -
C1P57_RS13810 (2730539) 2730539..2731902 - 1364 Protein_2676 PLP-dependent aminotransferase family protein -
C1P57_RS13815 (2731999) 2731999..2733345 + 1347 WP_000483769.1 IS4-like element IS4 family transposase -
C1P57_RS13820 (2733462) 2733462..2733878 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
C1P57_RS13825 (2733924) 2733924..2734100 - 177 WP_078166743.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
C1P57_RS13830 (2734322) 2734322..2734552 + 231 WP_000494244.1 YncJ family protein -
C1P57_RS13835 (2734644) 2734644..2736605 - 1962 WP_047085199.1 23S rRNA 5-hydroxycytidine C2501 synthase -
C1P57_RS13840 (2736678) 2736678..2737213 - 536 Protein_2682 DNA-binding transcriptional regulator SutR -
C1P57_RS13845 (2737266) 2737266..2738477 + 1212 WP_119172309.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2732017..2733345 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6765.87 Da        Isoelectric Point: 11.2298

>T96446 WP_078166743.1 NZ_CP026846:c2734100-2733924 [Shigella boydii]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHLCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T96446 NZ_CP026846:c2734100-2733924 [Shigella boydii]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCTCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT96446 WP_001270286.1 NZ_CP026846:c2733878-2733462 [Shigella boydii]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT96446 NZ_CP026846:c2733878-2733462 [Shigella boydii]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGAGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATAGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References