Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1438487..1439105 Replicon chromosome
Accession NZ_CP026846
Organism Shigella boydii strain 59-2708

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P57_RS07100 Protein ID WP_001291435.1
Coordinates 1438487..1438705 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag C1P57_RS07105 Protein ID WP_000344800.1
Coordinates 1438731..1439105 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P57_RS07070 (1433787) 1433787..1434014 + 228 WP_000513895.1 DUF2188 domain-containing protein -
C1P57_RS25115 (1434215) 1434215..1434496 + 282 WP_000566734.1 hypothetical protein -
C1P57_RS07080 (1435070) 1435070..1435423 + 354 WP_000878140.1 DUF1428 domain-containing protein -
C1P57_RS07085 (1435465) 1435465..1437015 - 1551 WP_078167394.1 cyclic-guanylate-specific phosphodiesterase PdeB -
C1P57_RS07090 (1437179) 1437179..1437649 - 471 WP_000136192.1 YlaC family protein -
C1P57_RS07095 (1437765) 1437765..1438316 - 552 WP_000102564.1 maltose O-acetyltransferase -
C1P57_RS07100 (1438487) 1438487..1438705 - 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P57_RS07105 (1438731) 1438731..1439105 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
C1P57_RS07110 (1439651) 1439651..1442799 - 3149 Protein_1385 efflux RND transporter permease AcrB -
C1P57_RS07115 (1442822) 1442822..1444015 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96434 WP_001291435.1 NZ_CP026846:c1438705-1438487 [Shigella boydii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96434 NZ_CP026846:c1438705-1438487 [Shigella boydii]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT96434 WP_000344800.1 NZ_CP026846:c1439105-1438731 [Shigella boydii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96434 NZ_CP026846:c1439105-1438731 [Shigella boydii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References