Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4325709..4326327 Replicon chromosome
Accession NZ_CP026828
Organism Shigella dysenteriae strain ATCC 12037

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P70_RS22870 Protein ID WP_001291435.1
Coordinates 4326109..4326327 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q325D5
Locus tag C1P70_RS22865 Protein ID WP_000344809.1
Coordinates 4325709..4326083 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P70_RS22855 (4320798) 4320798..4321991 + 1194 WP_134807265.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C1P70_RS22860 (4322014) 4322014..4325163 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
C1P70_RS22865 (4325709) 4325709..4326083 + 375 WP_000344809.1 Hha toxicity modulator TomB Antitoxin
C1P70_RS22870 (4326109) 4326109..4326327 + 219 WP_001291435.1 HHA domain-containing protein Toxin
C1P70_RS22875 (4326499) 4326499..4327050 + 552 WP_000102569.1 maltose O-acetyltransferase -
C1P70_RS22880 (4327166) 4327166..4327636 + 471 WP_000136192.1 YlaC family protein -
C1P70_RS22885 (4327951) 4327951..4329179 + 1229 WP_167544908.1 IS3-like element IS2 family transposase -
C1P70_RS22890 (4329190) 4329190..4329555 + 366 Protein_4403 CSS-motif domain-containing protein -
C1P70_RS22895 (4329620) 4329620..4330776 + 1157 WP_134807266.1 IS3-like element IS600 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T96280 WP_001291435.1 NZ_CP026828:4326109-4326327 [Shigella dysenteriae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T96280 NZ_CP026828:4326109-4326327 [Shigella dysenteriae]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14583.42 Da        Isoelectric Point: 4.5934

>AT96280 WP_000344809.1 NZ_CP026828:4325709-4326083 [Shigella dysenteriae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT96280 NZ_CP026828:4325709-4326083 [Shigella dysenteriae]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB Q325D5

References