Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2603017..2603852 Replicon chromosome
Accession NZ_CP026828
Organism Shigella dysenteriae strain ATCC 12037

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag C1P70_RS13285 Protein ID WP_134807077.1
Coordinates 2603017..2603394 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag C1P70_RS13290 Protein ID WP_001295723.1
Coordinates 2603484..2603852 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P70_RS13245 (2598431) 2598431..2599489 + 1059 WP_074499974.1 FUSC family protein -
C1P70_RS13250 (2599587) 2599587..2600284 + 698 WP_134795416.1 IS1-like element IS1SD family transposase -
C1P70_RS13255 (2600438) 2600438..2600767 + 330 WP_000450409.1 DUF496 family protein -
C1P70_RS26670 (2600868) 2600868..2601233 - 366 WP_252988891.1 EutP/PduV family microcompartment system protein -
C1P70_RS26675 (2601504) 2601504..2601875 - 372 WP_001295631.1 IS110 family transposase -
C1P70_RS26255 (2602691) 2602691..2602771 - 81 Protein_2557 hypothetical protein -
C1P70_RS13280 (2602817) 2602817..2603020 - 204 WP_000761705.1 DUF5983 family protein -
C1P70_RS13285 (2603017) 2603017..2603394 - 378 WP_134807077.1 TA system toxin CbtA family protein Toxin
C1P70_RS13290 (2603484) 2603484..2603852 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C1P70_RS13295 (2604015) 2604015..2604236 - 222 WP_112027073.1 DUF987 domain-containing protein -
C1P70_RS13300 (2604299) 2604299..2604775 - 477 WP_001186773.1 RadC family protein -
C1P70_RS13305 (2604791) 2604791..2605264 - 474 WP_134807078.1 antirestriction protein -
C1P70_RS13315 (2605606) 2605606..2606424 - 819 WP_134807079.1 DUF932 domain-containing protein -
C1P70_RS13325 (2606542) 2606542..2606737 - 196 Protein_2565 DUF905 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2599907..2600284 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14255.27 Da        Isoelectric Point: 6.9482

>T96267 WP_134807077.1 NZ_CP026828:c2603394-2603017 [Shigella dysenteriae]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSEF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T96267 NZ_CP026828:c2603394-2603017 [Shigella dysenteriae]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGAATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT96267 WP_001295723.1 NZ_CP026828:c2603852-2603484 [Shigella dysenteriae]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT96267 NZ_CP026828:c2603852-2603484 [Shigella dysenteriae]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References