Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4693613..4694267 Replicon chromosome
Accession NZ_CP026802
Organism Shigella sonnei strain ATCC 29930

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag C1P89_RS24240 Protein ID WP_000244777.1
Coordinates 4693860..4694267 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C1P89_RS24235 Protein ID WP_000354046.1
Coordinates 4693613..4693879 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P89_RS24210 (4688782) 4688782..4689525 + 744 WP_000951938.1 SDR family oxidoreductase -
C1P89_RS24215 (4689582) 4689582..4691015 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
C1P89_RS24220 (4691060) 4691060..4691371 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C1P89_RS24225 (4691535) 4691535..4692194 + 660 WP_000250274.1 hemolysin III family protein -
C1P89_RS24230 (4692390) 4692390..4693370 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
C1P89_RS24235 (4693613) 4693613..4693879 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C1P89_RS24240 (4693860) 4693860..4694267 + 408 WP_000244777.1 protein YgfX Toxin
C1P89_RS24245 (4694307) 4694307..4694828 - 522 WP_001055874.1 flavodoxin FldB -
C1P89_RS24250 (4694940) 4694940..4695836 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C1P89_RS24255 (4695861) 4695861..4696571 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1P89_RS24260 (4696577) 4696577..4698310 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T96051 WP_000244777.1 NZ_CP026802:4693860-4694267 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T96051 NZ_CP026802:4693860-4694267 [Shigella sonnei]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT96051 WP_000354046.1 NZ_CP026802:4693613-4693879 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT96051 NZ_CP026802:4693613-4693879 [Shigella sonnei]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References