Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2165611..2166445 Replicon chromosome
Accession NZ_CP026723
Organism Escherichia coli strain 266917_2

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag C4R22_RS11255 Protein ID WP_000854690.1
Coordinates 2166068..2166445 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag C4R22_RS11250 Protein ID WP_001305076.1
Coordinates 2165611..2165979 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4R22_RS11205 2160693..2161820 + 1128 Protein_2072 hypothetical protein -
C4R22_RS11210 2161896..2162351 + 456 WP_000581502.1 hypothetical protein -
C4R22_RS11215 2162430..2162663 + 234 WP_000902034.1 DUF905 family protein -
C4R22_RS11225 2162764..2163582 + 819 WP_016231181.1 DUF945 domain-containing protein -
C4R22_RS11230 2163637..2164122 + 486 WP_000849565.1 antirestriction protein -
C4R22_RS11235 2164138..2164614 + 477 WP_001186726.1 RadC family protein -
C4R22_RS11240 2164677..2164898 + 222 WP_000692329.1 DUF987 domain-containing protein -
C4R22_RS11245 2164917..2165561 + 645 WP_000094916.1 hypothetical protein -
C4R22_RS11250 2165611..2165979 + 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C4R22_RS11255 2166068..2166445 + 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
C4R22_RS11260 2166442..2166930 + 489 WP_000761699.1 hypothetical protein -
C4R22_RS11265 2166947..2167144 + 198 WP_000839293.1 DUF957 domain-containing protein -
C4R22_RS11270 2167229..2168074 + 846 WP_001529401.1 DUF4942 domain-containing protein -
C4R22_RS11275 2168143..2168538 + 396 WP_000208384.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
C4R22_RS11280 2168531..2169464 + 934 Protein_2086 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
C4R22_RS31465 2169896..2170051 + 156 WP_000729638.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2169896..2170051 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T95570 WP_000854690.1 NZ_CP026723:2166068-2166445 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T95570 NZ_CP026723:2166068-2166445 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT95570 WP_001305076.1 NZ_CP026723:2165611-2165979 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT95570 NZ_CP026723:2165611-2165979 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References