Detailed information of TA system TA095338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1487010..1487665
• Replicon: chromosome
• Accession: NZ_CP026633
• Organism: Bordetella pertussis strain J362

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: C4C66_RS07285
• Protein ID: WP_047122780.1
• Coordinates: 1487010..1487261 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: C4C66_RS07290
• Protein ID: WP_003809516.1
• Coordinates: 1487264..1487665 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4C66_RS07260	1482171..1483301	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
C4C66_RS07265	1483536..1484117	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
C4C66_RS07270	1484254..1485318	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
C4C66_RS07275	1485403..1485849	-	447	WP_003819827.1	GFA family protein	-
C4C66_RS07280	1486074..1486955	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
C4C66_RS07285	1487010..1487261	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
C4C66_RS07290	1487264..1487665	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
C4C66_RS07295	1487685..1487921	+	237	WP_010930404.1	membrane protein	-
C4C66_RS07300	1487929..1488408	+	480	WP_010930405.1	disulfide bond formation protein B	-
C4C66_RS07305	1488558..1489073	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
C4C66_RS07310	1489076..1490266	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
C4C66_RS07315	1490286..1491323	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
C4C66_RS07320	1491460..1492482	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T95338 WP_047122780.1 NZ_CP026633:1487010-1487261 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T95338 NZ_CP026633:1487010-1487261 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT95338 WP_003809516.1 NZ_CP026633:1487264-1487665 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT95338 NZ_CP026633:1487264-1487665 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6