Detailed information of TA system TA095299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1826847..1827435
• Replicon: chromosome
• Accession: NZ_CP026616
• Organism: Acinetobacter sp. SWBY1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9MLD7
• Locus tag: C3Y93_RS08785
• Protein ID: WP_005175534.1
• Coordinates: 1827139..1827435 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C3Y93_RS08780
• Protein ID: WP_004969304.1
• Coordinates: 1826847..1827137 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3Y93_RS08745	1822188..1822502	-	315	Protein_1696	exodeoxyribonuclease VII large subunit	-
C3Y93_RS08750	1822671..1823348	-	678	WP_104852705.1	recombinase family protein	-
C3Y93_RS08755	1823584..1824771	-	1188	WP_087551687.1	Tet(A)/Tet(B)/Tet(C) family tetracycline efflux MFS transporter	-
C3Y93_RS08760	1824837..1825478	+	642	WP_004787586.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
C3Y93_RS08765	1825759..1826070	+	312	WP_104853265.1	BrnT family toxin	-
C3Y93_RS08770	1826033..1826347	+	315	WP_038350244.1	BrnA antitoxin family protein	-
C3Y93_RS08780	1826847..1827137	-	291	WP_004969304.1	putative addiction module antidote protein	Antitoxin
C3Y93_RS08785	1827139..1827435	-	297	WP_005175534.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C3Y93_RS08790	1827607..1827876	+	270	WP_039048204.1	hypothetical protein	-
C3Y93_RS08795	1827956..1828063	+	108	WP_104852706.1	transposase domain-containing protein	-
C3Y93_RS08800	1828405..1829298	-	894	WP_019838313.1	LysR family transcriptional regulator	-
C3Y93_RS08805	1829348..1830700	-	1353	WP_019838314.1	MFS transporter	-
C3Y93_RS08810	1830969..1831889	-	921	WP_033917443.1	catechol 1,2-dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	tet(39) / blaOXA-58 / aph(3'')-Ib / aph(6)-Id / sul2 / floR	-	1819901..1867034	47133

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-91)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11568.25 Da
• Isoelectric Point: 5.8801

>T95299 WP_005175534.1 NZ_CP026616:c1827435-1827139 [Acinetobacter sp. SWBY1]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Nucleotide

• Length: 297 bp

>T95299 NZ_CP026616:c1827435-1827139 [Acinetobacter sp. SWBY1]
ATGATTGAAATTAAACGTCTGCCAGAGTTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGTATTCGCCTGAA
TCGTAGATTGGATAAGGTTCAACGTGGAAATTGGGGAGACATTAAGCCTCTTCAAGATGGCGTTTGGGAAATGAGAGAGT
TCTTCGGTGCTGGATGGAGAATGTATTACATCCAACATGGTGACGTAGTGATTGTAATGCTTGGTGGAGGAGATAAATCG
ACTCAACAACAAGATATCGATCGTGCAGTCAAATTATCGAAAACATTGGAGGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10524.19 Da
• Isoelectric Point: 5.1133

>AT95299 WP_004969304.1 NZ_CP026616:c1827137-1826847 [Acinetobacter sp. SWBY1]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHA

Nucleotide

• Length: 291 bp

>AT95299 NZ_CP026616:c1827137-1826847 [Acinetobacter sp. SWBY1]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCGCTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAGAATGATCCAGCTGAATTAGCCCATGCACTTGGCGTTATTGCTAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGACGTGAGGCACTCTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTTGTGAATGCTTTAGGCCTAAAACTCACAGTACAACATGCCTAA

Structures

Toxin

• AlphaFold DB: N9MLD7