Detailed information of TA system TA094851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 921..1543
• Replicon: plasmid unnamed
• Accession: NZ_CP026427
• Organism: Acinetobacter sp. ACNIH1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C3F22_RS18195
• Protein ID: WP_086185555.1
• Coordinates: 921..1316 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C3F22_RS18200
• Protein ID: WP_104427085.1
• Coordinates: 1313..1543 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F22_RS18440	1..88	-	88	Protein_0	BrnA antitoxin family protein	-
C3F22_RS18190	177..839	+	663	WP_104427084.1	hypothetical protein	-
C3F22_RS18195	921..1316	-	396	WP_086185555.1	type II toxin-antitoxin system VapC family toxin	Toxin
C3F22_RS18200	1313..1543	-	231	WP_104427085.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C3F22_RS18205	2268..2477	+	210	WP_005249157.1	hypothetical protein	-
C3F22_RS18210	2602..3483	+	882	WP_004282326.1	IS982-like element ISAba9 family transposase	-
C3F22_RS18215	3707..5161	+	1455	WP_005249159.1	SulP family inorganic anion transporter	-
C3F22_RS18220	5376..5921	-	546	WP_104427086.1	plasmid replication DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..8765	8765
	-	flank	IS/Tn	-	-	2602..3483	881

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14937.25 Da
• Isoelectric Point: 6.2238

>T94851 WP_086185555.1 NZ_CP026427:c1316-921 [Acinetobacter sp. ACNIH1]
MIYLLDTNICIYVINHKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLDILPYDEQAIWHYA
KLRQDLQSTGKTIGSLDMLIAAHALALDVVLVTNNIKEFERIDGLKLENWI

Nucleotide

• Length: 396 bp

>T94851 NZ_CP026427:c1316-921 [Acinetobacter sp. ACNIH1]
ATGATTTACCTCTTAGACACAAATATTTGTATCTACGTGATCAATCATAAACCACAGCAAGTTTTTGAACGCTTTAAGCA
ATATCAGCTTGGACAGTTAGCTATTTCTAGCATAACCGCGTCAGAGCTGGCTTTTGGCGTTGAAAAGTCTGGATCTGAAC
GCAATAAGCAAGCTCTGAACAAGTTTTTATCACCCTTAGATATTTTACCCTACGATGAGCAAGCGATTTGGCATTACGCT
AAATTACGTCAAGATCTCCAATCAACAGGTAAAACTATTGGTAGTTTAGATATGCTAATAGCAGCTCATGCCCTCGCTTT
AGATGTTGTACTAGTCACAAACAACATCAAGGAATTTGAGCGTATAGATGGGTTAAAGTTAGAGAACTGGATCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8733.00 Da
• Isoelectric Point: 4.7708

>AT94851 WP_104427085.1 NZ_CP026427:c1543-1313 [Acinetobacter sp. ACNIH1]
METAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIENPWDIMLEAINEFEVGFQLERADQGEQLREDFK

Nucleotide

• Length: 231 bp

>AT94851 NZ_CP026427:c1543-1313 [Acinetobacter sp. ACNIH1]
ATGGAAACCGCTAAAGTTTTTCAAACAGGTCGTAGTCAAGCTGTCCGTTTACCTAAAGCATTTCGCTTTAATGGTACTGA
AGTTGCTATCAAGAGTTTTGGCCGTGGTGTCTTATTAATGCCCATCGAAAACCCATGGGACATCATGTTAGAAGCAATTA
ACGAATTTGAAGTAGGATTTCAGCTTGAACGAGCTGATCAGGGTGAGCAATTACGTGAGGACTTCAAATGA