Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 202304..202826 | Replicon | plasmid pA708-1 |
Accession | NZ_CP026369 | ||
Organism | Klebsiella quasipneumoniae strain A708 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A7H0EVH6 |
Locus tag | C2767_RS28335 | Protein ID | WP_014839901.1 |
Coordinates | 202542..202826 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | A0A7H0EVH5 |
Locus tag | C2767_RS28330 | Protein ID | WP_014839900.1 |
Coordinates | 202304..202552 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C2767_RS28295 | 197524..198345 | + | 822 | WP_014839898.1 | phospholipase D family protein | - |
C2767_RS28300 | 198590..199384 | + | 795 | WP_017901072.1 | DUF4942 domain-containing protein | - |
C2767_RS28305 | 199765..200121 | + | 357 | WP_017901071.1 | hypothetical protein | - |
C2767_RS28310 | 200495..200893 | + | 399 | WP_014839899.1 | H-NS histone family protein | - |
C2767_RS28315 | 201030..201638 | + | 609 | WP_024266306.1 | DUF2913 family protein | - |
C2767_RS28330 | 202304..202552 | + | 249 | WP_014839900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
C2767_RS28335 | 202542..202826 | + | 285 | WP_014839901.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C2767_RS28340 | 203017..203493 | + | 477 | WP_042934526.1 | hypothetical protein | - |
C2767_RS28345 | 203499..204176 | + | 678 | WP_042934501.1 | hypothetical protein | - |
C2767_RS28350 | 204193..204912 | - | 720 | WP_042934502.1 | cation:proton antiporter | - |
C2767_RS28355 | 205153..205755 | - | 603 | WP_014839902.1 | hypothetical protein | - |
C2767_RS28360 | 205752..206273 | - | 522 | WP_048336588.1 | hypothetical protein | - |
C2767_RS28365 | 206354..207298 | - | 945 | WP_014839903.1 | DsbA family protein | - |
C2767_RS28370 | 207361..207570 | - | 210 | WP_125316032.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaIMP-4 / blaSFO-1 / aac(3)-IId / blaTEM-1B / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 | - | 1..238703 | 238703 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10866.46 Da Isoelectric Point: 10.5831
>T94728 WP_014839901.1 NZ_CP026369:202542-202826 [Klebsiella quasipneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN
Download Length: 285 bp
>T94728 NZ_CP026369:202542-202826 [Klebsiella quasipneumoniae]
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9071.29 Da Isoelectric Point: 3.8832
>AT94728 WP_014839900.1 NZ_CP026369:202304-202552 [Klebsiella quasipneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL
Download Length: 249 bp
>AT94728 NZ_CP026369:202304-202552 [Klebsiella quasipneumoniae]
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7H0EVH6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7H0EVH5 |