Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 202304..202826 Replicon plasmid pA708-1
Accession NZ_CP026369
Organism Klebsiella quasipneumoniae strain A708

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag C2767_RS28335 Protein ID WP_014839901.1
Coordinates 202542..202826 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag C2767_RS28330 Protein ID WP_014839900.1
Coordinates 202304..202552 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2767_RS28295 197524..198345 + 822 WP_014839898.1 phospholipase D family protein -
C2767_RS28300 198590..199384 + 795 WP_017901072.1 DUF4942 domain-containing protein -
C2767_RS28305 199765..200121 + 357 WP_017901071.1 hypothetical protein -
C2767_RS28310 200495..200893 + 399 WP_014839899.1 H-NS histone family protein -
C2767_RS28315 201030..201638 + 609 WP_024266306.1 DUF2913 family protein -
C2767_RS28330 202304..202552 + 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C2767_RS28335 202542..202826 + 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2767_RS28340 203017..203493 + 477 WP_042934526.1 hypothetical protein -
C2767_RS28345 203499..204176 + 678 WP_042934501.1 hypothetical protein -
C2767_RS28350 204193..204912 - 720 WP_042934502.1 cation:proton antiporter -
C2767_RS28355 205153..205755 - 603 WP_014839902.1 hypothetical protein -
C2767_RS28360 205752..206273 - 522 WP_048336588.1 hypothetical protein -
C2767_RS28365 206354..207298 - 945 WP_014839903.1 DsbA family protein -
C2767_RS28370 207361..207570 - 210 WP_125316032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaIMP-4 / blaSFO-1 / aac(3)-IId / blaTEM-1B / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 - 1..238703 238703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T94728 WP_014839901.1 NZ_CP026369:202542-202826 [Klebsiella quasipneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T94728 NZ_CP026369:202542-202826 [Klebsiella quasipneumoniae]
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT94728 WP_014839900.1 NZ_CP026369:202304-202552 [Klebsiella quasipneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT94728 NZ_CP026369:202304-202552 [Klebsiella quasipneumoniae]
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References