Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2841273..2841952 Replicon chromosome
Accession NZ_CP026338
Organism Acinetobacter baumannii strain 810CP

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S4SYJ5
Locus tag Aba810CP_RS13840 Protein ID WP_002108505.1
Coordinates 2841770..2841952 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag Aba810CP_RS13835 Protein ID WP_000966688.1
Coordinates 2841273..2841677 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba810CP_RS13815 2839442..2840188 - 747 WP_000599536.1 hypothetical protein -
Aba810CP_RS13820 2840250..2840633 - 384 WP_000725050.1 hypothetical protein -
Aba810CP_RS13825 2840666..2840989 - 324 WP_000523928.1 DUF4236 domain-containing protein -
Aba810CP_RS13830 2840998..2841174 - 177 WP_075149899.1 hypothetical protein -
Aba810CP_RS13835 2841273..2841677 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Aba810CP_RS13840 2841770..2841952 - 183 WP_002108505.1 type II toxin-antitoxin system HicA family toxin Toxin
Aba810CP_RS13850 2842278..2842793 - 516 WP_001185610.1 hypothetical protein -
Aba810CP_RS13855 2842863..2843780 - 918 WP_000094249.1 hypothetical protein -
Aba810CP_RS13860 2843833..2844981 - 1149 WP_114623140.1 phage tail protein -
Aba810CP_RS13865 2844981..2845334 - 354 WP_031975507.1 hypothetical protein -
Aba810CP_RS13870 2845430..2845648 - 219 WP_001277694.1 hypothetical protein -
Aba810CP_RS13875 2845650..2846048 - 399 WP_025466443.1 hypothetical protein -
Aba810CP_RS13880 2846050..2846418 - 369 WP_025466445.1 hypothetical protein -
Aba810CP_RS13885 2846390..2846797 - 408 WP_000255076.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2825402..2875477 50075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6685.80 Da        Isoelectric Point: 10.5523

>T93844 WP_002108505.1 NZ_CP026338:c2841952-2841770 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTISHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T93844 NZ_CP026338:c2841952-2841770 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT93844 WP_000966688.1 NZ_CP026338:c2841677-2841273 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT93844 NZ_CP026338:c2841677-2841273 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4SYJ5

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References