93781

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 81016..81606 Replicon chromosome
Accession NZ_CP026275
Organism Klebsiella oxytoca strain KONIH5

Toxin (Protein)


Gene name pemK Uniprot ID A0A1D8JW90
Locus tag C2U46_RS00390 Protein ID WP_032693748.1
Coordinates 81016..81348 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID J6I3K7
Locus tag C2U46_RS00395 Protein ID WP_004852307.1
Coordinates 81349..81606 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U46_RS00365 76179..76982 - 804 WP_003036327.1 TIGR02391 family protein -
C2U46_RS00370 77004..77483 - 480 WP_031617716.1 hypothetical protein -
C2U46_RS00375 77562..78500 - 939 WP_003036321.1 hypothetical protein -
C2U46_RS00385 79336..80697 + 1362 WP_003036316.1 hypothetical protein -
C2U46_RS00390 81016..81348 - 333 WP_032693748.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C2U46_RS00395 81349..81606 - 258 WP_004852307.1 antitoxin Antitoxin
C2U46_RS00405 81867..82060 - 194 Protein_77 helix-turn-helix domain-containing protein -
C2U46_RS00410 82057..82530 - 474 WP_050595132.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11752.67 Da        Isoelectric Point: 10.4751

>T93781 WP_032693748.1 NZ_CP026275:c81348-81016 [Klebsiella oxytoca]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLARLPVVVPITSGGKFARTAGFTVSLEGAGTKTTGVIRCDQPRTI
DMVARNGKRLESIPDAVVNEVLARLDAILS

Download         Length: 333 bp

>T93781 NZ_CP026275:c81348-81016 [Klebsiella oxytoca]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGGCCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAAATTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCAGGGACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGTTGCCCGGAACGGCAAGCGGCTGGAAAGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTAAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9422.88 Da        Isoelectric Point: 4.4607

>AT93781 WP_004852307.1 NZ_CP026275:c81606-81349 [Klebsiella oxytoca]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT93781 NZ_CP026275:c81606-81349 [Klebsiella oxytoca]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGCTCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATAGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JW90

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HDW8

References