Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4716024..4716540 Replicon chromosome
Accession NZ_CP026159
Organism Klebsiella pneumoniae strain F89-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag C2M18_RS23555 Protein ID WP_009486548.1
Coordinates 4716024..4716308 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2M18_RS23560 Protein ID WP_002886901.1
Coordinates 4716298..4716540 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2M18_RS23530 4711420..4711728 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
C2M18_RS27230 4711813..4711986 + 174 WP_004222159.1 hypothetical protein -
C2M18_RS23535 4711989..4712732 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C2M18_RS23545 4713089..4715227 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C2M18_RS23550 4715556..4716020 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2M18_RS23555 4716024..4716308 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2M18_RS23560 4716298..4716540 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2M18_RS23565 4716618..4718528 - 1911 WP_004152270.1 BglG family transcription antiterminator -
C2M18_RS23570 4718551..4719705 - 1155 WP_129059957.1 lactonase family protein -
C2M18_RS23575 4719772..4720512 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T93565 WP_009486548.1 NZ_CP026159:c4716308-4716024 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T93565 NZ_CP026159:c4716308-4716024 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT93565 WP_002886901.1 NZ_CP026159:c4716540-4716298 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT93565 NZ_CP026159:c4716540-4716298 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGTGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References