Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 3014273..3014786 Replicon chromosome
Accession NZ_CP026125
Organism Acinetobacter baumannii strain ABNIH28

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2L2M0A2
Locus tag C2U32_RS14950 Protein ID WP_000203952.1
Coordinates 3014273..3014536 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag C2U32_RS14955 Protein ID WP_000557943.1
Coordinates 3014523..3014786 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U32_RS14915 3010363..3011793 + 1431 WP_000178999.1 amino acid permease -
C2U32_RS14920 3011851..3012195 - 345 Protein_2894 LysR family transcriptional regulator -
C2U32_RS14925 3012234..3013467 - 1234 Protein_2895 IS3 family transposase -
C2U32_RS14930 3013526..3013843 - 318 Protein_2896 LysR family transcriptional regulator -
C2U32_RS14940 3013977..3014075 + 99 Protein_2897 IS5/IS1182 family transposase -
C2U32_RS14945 3014107..3014214 - 108 Protein_2898 transposase domain-containing protein -
C2U32_RS14950 3014273..3014536 - 264 WP_000203952.1 Txe/YoeB family addiction module toxin Toxin
C2U32_RS14955 3014523..3014786 - 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C2U32_RS14960 3015202..3018549 + 3348 WP_103270920.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10664.10 Da        Isoelectric Point: 8.4894

>T93357 WP_000203952.1 NZ_CP026125:c3014536-3014273 [Acinetobacter baumannii]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Download         Length: 264 bp

>T93357 NZ_CP026125:c3014536-3014273 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT93357 WP_000557943.1 NZ_CP026125:c3014786-3014523 [Acinetobacter baumannii]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT93357 NZ_CP026125:c3014786-3014523 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L2M0A2

Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References