Detailed information of TA system TA093334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 2303555..2304223
• Replicon: chromosome
• Accession: NZ_CP026112
• Organism: Paraburkholderia terrae strain DSM 17804

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A2I8EWC1
• Locus tag: C2L65_RS26535
• Protein ID: WP_042316670.1
• Coordinates: 2303882..2304223 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C2L65_RS26530
• Protein ID: WP_042316643.1
• Coordinates: 2303555..2303866 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2L65_RS26515	2299905..2301188	+	1284	WP_042306565.1	4-aminobutyrate--2-oxoglutarate transaminase	-
C2L65_RS26525	2301994..2303460	+	1467	WP_042316640.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
C2L65_RS26530	2303555..2303866	-	312	WP_042316643.1	helix-turn-helix domain-containing protein	Antitoxin
C2L65_RS26535	2303882..2304223	-	342	WP_042316670.1	toxin	Toxin
C2L65_RS26540	2304797..2305771	-	975	WP_042316646.1	lipoyl synthase	-
C2L65_RS26545	2305774..2306886	-	1113	WP_042316649.1	acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit	-
C2L65_RS26550	2306902..2307906	-	1005	WP_042316651.1	alpha-ketoacid dehydrogenase subunit beta	-
C2L65_RS26555	2308001..2308978	-	978	WP_042316654.1	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-87)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13233.30 Da
• Isoelectric Point: 9.3431

>T93334 WP_042316670.1 NZ_CP026112:c2304223-2303882 [Paraburkholderia terrae]
MAATFVELAPFRRCREDYLMDDEYRALQIVLMQNPEAGDVVRGTGGLRKLRFGDARRGKGKRGGLRVMYYYWVKGPQFWM
FTLYDKDEVEDLSSKERGVLSEMLREVIKLADR

Nucleotide

• Length: 342 bp

>T93334 NZ_CP026112:c2304223-2303882 [Paraburkholderia terrae]
ATGGCGGCGACTTTCGTCGAACTGGCGCCTTTTCGACGGTGCCGGGAAGACTATTTGATGGACGACGAATATCGCGCACT
CCAGATTGTGCTGATGCAGAACCCGGAAGCGGGAGATGTCGTCAGGGGAACGGGCGGTCTGCGCAAACTCCGTTTCGGCG
ACGCACGTCGTGGGAAGGGAAAACGCGGCGGGCTCAGGGTGATGTATTACTACTGGGTGAAAGGCCCGCAGTTCTGGATG
TTCACGCTATACGACAAGGACGAAGTGGAAGATTTATCGTCGAAGGAGCGAGGGGTTCTCTCCGAGATGCTGAGAGAAGT
CATCAAGCTTGCGGATCGATAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11861.63 Da
• Isoelectric Point: 9.7633

>AT93334 WP_042316643.1 NZ_CP026112:c2303866-2303555 [Paraburkholderia terrae]
MKRNLFAELTEGLDELKSAHEGKTTLHKVKVEIRDKLEVTADEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIRLVEKHPETIQMLETL

Nucleotide

• Length: 312 bp

>AT93334 NZ_CP026112:c2303866-2303555 [Paraburkholderia terrae]
ATGAAACGGAATCTGTTTGCCGAATTGACGGAAGGGCTCGATGAACTCAAGTCCGCTCACGAAGGCAAGACAACACTTCA
CAAGGTCAAGGTTGAGATTCGTGACAAGCTGGAAGTGACGGCTGACGAGATCCGGGCCGTCCGGGAATCCATCAACGCGT
CGCAGGCGGTTATGGCGCGTCGTCTGCGCGTGAACGAGCGGACCTACCAGAATTGGGAGCAAGGGCGAGCGAAGCCGAAC
GCCCAGGCTGCTGTGCTGATCAGGCTGGTTGAAAAGCATCCTGAGACGATACAGATGCTCGAAACCCTATGA

Structures

Toxin

• AlphaFold DB: A0A2I8EWC1