Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3152951..3154701 Replicon chromosome
Accession NZ_CP026106
Organism Paraburkholderia hospita strain DSM 17164

Toxin (Protein)


Gene name doc Uniprot ID A0A1H6ISX3
Locus tag C2L64_RS32615 Protein ID WP_007587791.1
Coordinates 3153808..3154701 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7Z7FI85
Locus tag C2L64_RS32610 Protein ID WP_007587790.1
Coordinates 3152951..3153811 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L64_RS32590 3148147..3149643 - 1497 WP_007587785.1 aldehyde dehydrogenase -
C2L64_RS32595 3149671..3150501 - 831 WP_007587786.1 aspartate dehydrogenase -
C2L64_RS32600 3150494..3152152 - 1659 WP_007587787.1 thiamine pyrophosphate-binding protein -
C2L64_RS32605 3152145..3152951 - 807 WP_007587788.1 SDR family oxidoreductase -
C2L64_RS32610 3152951..3153811 - 861 WP_007587790.1 IclR family transcriptional regulator Antitoxin
C2L64_RS32615 3153808..3154701 - 894 WP_007587791.1 alpha/beta fold hydrolase Toxin
C2L64_RS32620 3154727..3155266 - 540 WP_007587792.1 cupin domain-containing protein -
C2L64_RS32625 3155302..3156057 - 756 WP_007587793.1 SDR family oxidoreductase -
C2L64_RS32630 3156050..3157138 - 1089 WP_007587794.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
C2L64_RS32635 3157193..3157504 - 312 WP_007587795.1 hypothetical protein -
C2L64_RS32640 3157506..3157823 - 318 WP_007587796.1 non-heme iron oxygenase ferredoxin subunit -
C2L64_RS32645 3158300..3159337 + 1038 WP_176133756.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-275)

Antitoxin

Transcription regulator IclR, N-terminal

(26-74)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31386.35 Da        Isoelectric Point: 6.4084

>T93326 WP_007587791.1 NZ_CP026106:c3154701-3153808 [Paraburkholderia hospita]
MSAALPVTVDRNATLETRLSHFPAQRIAIAPQRTIGYREAGAAHADALPLVLLHGIGSGAASWVQQFEALGTTRRVFAWD
APGYGESTPVASASPEAHEYAGALNAWLDALDVERCVLVGHSLGAIIAGSFAASHAERVAGLLLISPAAGYGAASEEVRA
SKRDGRLAMLAELGPQVLAEKRSANMLSPHADDASREWVRWNMSRIVPNGYAQATHLLANTDLASDLAKFNGRIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEADTEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T93326 NZ_CP026106:c3154701-3153808 [Paraburkholderia hospita]
ATGTCCGCAGCCTTGCCCGTTACTGTCGATCGAAACGCCACACTGGAAACGCGCCTCTCGCACTTCCCGGCACAGCGGAT
CGCGATTGCGCCGCAACGTACGATCGGTTATCGCGAAGCGGGTGCCGCACACGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGCTCGGGCGCGGCTTCGTGGGTGCAACAGTTCGAAGCGCTCGGCACGACGCGCCGCGTGTTCGCGTGGGAC
GCGCCGGGCTACGGCGAATCGACACCCGTTGCGTCGGCTTCGCCGGAAGCACATGAATATGCTGGCGCGCTCAACGCATG
GCTCGACGCGCTCGACGTAGAGCGTTGCGTACTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCTCGTTCGCAGCGT
CGCACGCGGAACGCGTCGCGGGGCTGTTGCTGATTTCGCCCGCAGCGGGCTACGGCGCGGCATCCGAAGAAGTGCGCGCG
TCGAAGCGCGACGGCCGTCTCGCGATGCTCGCCGAACTCGGCCCGCAGGTACTCGCGGAAAAACGCAGCGCCAACATGCT
CTCGCCGCACGCCGACGACGCATCGCGCGAGTGGGTTCGCTGGAACATGTCGCGCATCGTGCCGAACGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACACGGACCTCGCCAGCGATCTCGCGAAGTTCAACGGCCGTATCGCTGTCGCGGTCGGCGCG
GAAGACTCGATCACGCCGCCGTCGTCATGCGAGCGGATTGCGCAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTATATCGAAGCGGACACTGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGCCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31480.89 Da        Isoelectric Point: 6.5092

>AT93326 WP_007587790.1 NZ_CP026106:c3153811-3152951 [Paraburkholderia hospita]
MTPELTGTAPEAEDDRNDANYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRSAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT93326 NZ_CP026106:c3153811-3152951 [Paraburkholderia hospita]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAACTATCGGGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGCCTCGGCA
TTCCACGCACGACGGTGTTCCGGCTGTTGCAGACGCTCGAATCGCTCGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAGTATCTCAGCTCGCTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGTTTGCGCGACGCGACGGGCCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGCCACGCGCCCGTGTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGGCTACCCGCGCATGCGACGACGCAT
GGTCATGTACTGATGGGTGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTTGAACGCTTCACGAA
ACACACGCCCGCCACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGTTTCGCAATCAGCGAATCGT
CCTTTGAAAACGGCATTTCGGTGATCAGCGCGCCCGTGCGTAACGACACGGGGCGCATCGCCGCTGTCATCACGACGACG
ATTCCGCGTCCGCAGATCGACGCGGCGCTGCTTGATGGCGGCCTGATCGACAAGGTGCGTAGCGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTATCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H6ISX3

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7FI85

References