Detailed information of TA system TA093120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 734741..735273
• Replicon: chromosome
• Accession: NZ_CP026072
• Organism: Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: RK93_RS03740
• Protein ID: WP_001103942.1
• Coordinates: 734741..735061 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: RK93_RS03745
• Protein ID: WP_001058486.1
• Coordinates: 735064..735273 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK93_RS03710	729889..730230	-	342	WP_001190615.1	hypothetical protein	-
RK93_RS03715	730747..731388	-	642	WP_001019764.1	hypothetical protein	-
RK93_RS03720	731385..731669	-	285	WP_000998181.1	hypothetical protein	-
RK93_RS03725	731671..732033	-	363	WP_001039168.1	hypothetical protein	-
RK93_RS03730	732334..733791	-	1458	WP_000390455.1	virulence-associated E family protein	-
RK93_RS03735	733808..734677	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
RK93_RS03740	734741..735061	-	321	WP_001103942.1	DUF1474 family protein	Toxin
RK93_RS03745	735064..735273	-	210	WP_001058486.1	hypothetical protein	Antitoxin
RK93_RS03750	735266..735412	-	147	WP_000784875.1	hypothetical protein	-
RK93_RS03755	735424..735696	-	273	WP_000091733.1	helix-turn-helix domain-containing protein	-
RK93_RS03760	735689..735952	-	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
RK93_RS03765	736145..736477	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
RK93_RS03770	736489..736947	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
RK93_RS03775	736964..737395	+	432	WP_001228759.1	hypothetical protein	-
RK93_RS03780	737465..738193	+	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
RK93_RS03785	738217..738945	+	729	WP_000733775.1	staphylococcal enterotoxin type K	-
RK93_RS03790	739034..740254	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk / vWbp	724939..771482	46543

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T93120 WP_001103942.1 NZ_CP026072:c735061-734741 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T93120 NZ_CP026072:c735061-734741 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT93120 WP_001058486.1 NZ_CP026072:c735273-735064 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT93120 NZ_CP026072:c735273-735064 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4