Detailed information of TA system TA092935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 38670..39205
• Replicon: plasmid unnamed2
• Accession: NZ_CP026049
• Organism: Raoultella planticola strain FDAARGOS_64

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6M4NRI2
• Locus tag: MC50_RS27565
• Protein ID: WP_032693963.1
• Coordinates: 38918..39205 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2A2B7
• Locus tag: MC50_RS27560
• Protein ID: WP_032752108.1
• Coordinates: 38670..38921 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC50_RS27530	34039..34318	-	280	Protein_48	hypothetical protein	-
MC50_RS27535	34636..34866	-	231	WP_047665741.1	hypothetical protein	-
MC50_RS27540	34930..35601	-	672	WP_032700854.1	plasmid partitioning/stability family protein	-
MC50_RS27545	35604..36575	-	972	WP_077255421.1	StbA family protein	-
MC50_RS27550	36794..37237	+	444	WP_040118420.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
MC50_RS27555	37237..38505	+	1269	WP_047665742.1	Y-family DNA polymerase	-
MC50_RS27560	38670..38921	+	252	WP_032752108.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MC50_RS27565	38918..39205	+	288	WP_032693963.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC50_RS27575	40256..40573	+	318	WP_032752112.1	hypothetical protein	-
MC50_RS27580	41371..42342	-	972	WP_032752114.1	ParB/RepB/Spo0J family plasmid partition protein	-
MC50_RS27585	42342..43508	-	1167	WP_032752115.1	plasmid-partitioning protein SopA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..206855	206855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11133.12 Da
• Isoelectric Point: 10.2246

>T92935 WP_032693963.1 NZ_CP026049:38918-39205 [Raoultella planticola]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Nucleotide

• Length: 288 bp

>T92935 NZ_CP026049:38918-39205 [Raoultella planticola]
ATGACTTATACGGTCAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAGCTGGATAAGGCCATTCAGCAGCAGTTTGC
GAAGAAACTGAAGAAGTGCTGTGACGAACCACATATCCCTTCAGCAAAGCTGAGAGGAATAAAGGACTGCTACAAAATTA
AACTTCGTGCATCAGGTTTTCGCCTGGTGTATCAGGTGATAGATGATCAATTAATTATCGCGGTTGTTGCTGTTGGAAAG
CGTGAACGCAGTGACGTGTACAATCTGGCCAGCGAAAGGATGAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9174.43 Da
• Isoelectric Point: 3.9507

>AT92935 WP_032752108.1 NZ_CP026049:38670-38921 [Raoultella planticola]
MPNIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDALDDQELAKLVSERSNQQLLDVDLD
TYL

Nucleotide

• Length: 252 bp

>AT92935 NZ_CP026049:38670-38921 [Raoultella planticola]
ATGCCCAACATTATTCTGAGTGACACAAGCGCGAGCATCAGCGAACTAAAAAAAAATCCGATGGCGACGGTCAGTGCCGG
CGACGGCTTCCCGGTCGCGATTCTGAACCGTAACCAGCCGGCTTTTTACTGCATCCCGGCTGAACTTTACGAGAAGATGC
TCGATGCCCTGGATGATCAGGAACTGGCAAAGCTGGTATCAGAACGCAGTAACCAGCAGCTGCTTGACGTGGATCTGGAT
ACTTATCTATGA

Structures

Toxin

• AlphaFold DB: A0A6M4NRI2