Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4067224..4067821 Replicon chromosome
Accession NZ_CP026013
Organism Klebsiella variicola strain 13450

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2D62_RS19655 Protein ID WP_012968756.1
Coordinates 4067504..4067821 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2D62_RS19650 Protein ID WP_012542525.1
Coordinates 4067224..4067511 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2D62_RS19620 4063254..4063502 + 249 WP_022064667.1 DUF1158 domain-containing protein -
C2D62_RS19625 4063519..4063860 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
C2D62_RS19630 4063891..4065006 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
C2D62_RS19635 4065186..4065767 + 582 WP_046881940.1 TetR/AcrR family transcriptional regulator -
C2D62_RS19640 4065767..4066135 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
C2D62_RS19645 4066255..4066908 + 654 WP_039102940.1 oxygen-insensitive NAD(P)H nitroreductase -
C2D62_RS19650 4067224..4067511 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
C2D62_RS19655 4067504..4067821 - 318 WP_012968756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2D62_RS19660 4068006..4069049 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
C2D62_RS19665 4069576..4070442 - 867 WP_022065427.1 helix-turn-helix transcriptional regulator -
C2D62_RS19670 4070551..4071978 + 1428 WP_022065426.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12124.41 Da        Isoelectric Point: 11.2767

>T92687 WP_012968756.1 NZ_CP026013:c4067821-4067504 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
IKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T92687 NZ_CP026013:c4067821-4067504 [Klebsiella variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
ATCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT92687 WP_012542525.1 NZ_CP026013:c4067511-4067224 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp

>AT92687 NZ_CP026013:c4067511-4067224 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References