92648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2008528..2010185 Replicon chromosome
Accession NZ_CP026009
Organism Actinobacillus pleuropneumoniae strain App6

Toxin (Protein)


Gene name hipA Uniprot ID A3N2X8
Locus tag CYK57_RS09425 Protein ID WP_011848633.1
Coordinates 2008854..2010185 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A3N2X7
Locus tag CYK57_RS09420 Protein ID WP_005613259.1
Coordinates 2008528..2008857 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYK57_RS09400 2005858..2006475 + 618 WP_009874973.1 dimethylsulfoxide reductase subunit B -
CYK57_RS09405 2006477..2007310 + 834 WP_009874972.1 dimethyl sulfoxide reductase anchor subunit -
CYK57_RS09410 2007366..2007971 + 606 WP_009874971.1 Tat proofreading chaperone DmsD -
CYK57_RS09415 2007975..2008484 + 510 WP_009874970.1 ferredoxin-type protein NapF -
CYK57_RS09420 2008528..2008857 - 330 WP_005613259.1 helix-turn-helix domain-containing protein Antitoxin
CYK57_RS09425 2008854..2010185 - 1332 WP_011848633.1 type II toxin-antitoxin system HipA family toxin Toxin
CYK57_RS09430 2010517..2012208 - 1692 WP_042655118.1 AIPR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(164-371)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51131.07 Da        Isoelectric Point: 5.0347

>T92648 WP_011848633.1 NZ_CP026009:c2010185-2008854 [Actinobacillus pleuropneumoniae]
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHADKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAMVGG
ATGAGGEAPKLLLKCQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNIISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNPQEFAGEYRFDKIADGLSDLIEPDILLRELR
MLATQLVDLKSRLMKRGVPKSILDFPAIGFDYLPEKLQRWGLV

Download         Length: 1332 bp

>T92648 NZ_CP026009:c2010185-2008854 [Actinobacillus pleuropneumoniae]
ATGAGTGATATATCAGTCAAAAATAAAAAATTAACATTGCAGACCTATGTTGATAATCTATGGCGAGATATGGCGGAGCT
TTATTTCAATGCTCAGTATGAATTAGAGAGCATGGAATATTTAACGGACTATGCCGTCGATTTTTTTGGGCAAGCGAATG
CCAGATCCATATCAATTAATTATCCTGTAAATGTGTTTATTGATCATGCCGATAAGCTGATGACTACACTTGCCGATATT
ATTCCTGCCGGAGCGAGTCGGCGTTATTGGCTGGAAGCTCTTGATATCAAGCACCTATCTATTTCTCATCAAAATTACTT
ATTGCTAAAAAATGGCGCAATATCCCCTATCGGCAATGTCCGAGTTAAAGAGGCTGTGCCAGAAATACAAAGTGAGCGTT
ATTTTCCATTAAATGTGGTACAAAACAGGCAGAGTGATTTTTTAGAATATGCAAATCAGACAGGAGCTATGGTAGGCGGA
GCGACTGGGGCTGGGGGAGAAGCACCAAAGCTATTACTTAAATGCCAAGATAAACAAGTTTGGATTGATAATTTACAATT
AGGTCTAGATTGCGATACGGCTTATTTAGTGAAATATCCTCGTGGGAATTATTCAGAGTTGGACTGTGATATTTTAAGAG
CTGAATATCATTATTATCATGAGCTGCGTGCATTAGGGTTTTCAACTATAGATACTGATCTAATGAAATTAGAAGAGGGG
GAACGTTATCCGTCTTTATGGCTACCTAGATTCGATATGAAGTTCAAAGATGGAAAATGGGAGCGATATGCTATGGAATC
GGTTTATTCTATGTTACAAAAATATGGTGGAAATCTTGATCATGAGCAGACTATTCGCAACTTACTCAATATTATTTCAG
CTTCGCAATTTTCTAATGATTTTGATAACCGGCATTTTGTTATTGAATGGGTAAAGCGAGATTTGTTGAATATTGCTTTT
GGAAATAGTGATAATCATGGCAGAAATACTGCATTTTTACGTGATGATAATCGTATTTGGCTATCCCCTATCTATGATTT
TGCTCCGATGCGGGCAGATCCGGAAGGCATTATCAGAACGACCACTTGGGCTAAAAATGGAGATAACCCTCAAGAGTTCG
CCGGAGAATATCGCTTTGATAAAATAGCTGACGGTTTATCTGACCTTATTGAACCAGATATATTGTTAAGAGAATTAAGA
ATGCTTGCTACCCAATTAGTAGATTTAAAATCTAGACTTATGAAGCGAGGTGTTCCGAAAAGTATTTTAGATTTTCCCGC
CATTGGTTTTGATTACTTACCTGAGAAGTTACAACGTTGGGGGCTGGTATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12320.45 Da        Isoelectric Point: 10.8292

>AT92648 WP_005613259.1 NZ_CP026009:c2008857-2008528 [Actinobacillus pleuropneumoniae]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Download         Length: 330 bp

>AT92648 NZ_CP026009:c2008857-2008528 [Actinobacillus pleuropneumoniae]
ATGACGATTCAACATAAAAATGCCTCACCGACGCGATCTAAAGTGAATGGCATTGAACGACAATTAATCCGTGAAACGAT
TATAGTACAGCTCTTAAAAGGTGAGATTAGTCAAGGACAAGCACTACGTCGATTACGGGTAGAAGCATTAGGAATAAACC
AGCAAGATTATCTAAAATTAGCGAAAGTTTCTCGGCAAACGCTTTCTAATATCGAAAATGATAAAGGAAACTATAGTATA
GAGACAATTAATCAGGTATTTAAACCGATGGGACTAAAGCTAGGTCTTATGCCGATCTCAAAAGACTTGATGGCTTCCTT
TCTTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N2X8

Antitoxin

Source ID Structure
AlphaFold DB A3N2X7

References