Detailed information of TA system TA092648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2008528..2010185
• Replicon: chromosome
• Accession: NZ_CP026009
• Organism: Actinobacillus pleuropneumoniae strain App6

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A3N2X8
• Locus tag: CYK57_RS09425
• Protein ID: WP_011848633.1
• Coordinates: 2008854..2010185 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A3N2X7
• Locus tag: CYK57_RS09420
• Protein ID: WP_005613259.1
• Coordinates: 2008528..2008857 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYK57_RS09400	2005858..2006475	+	618	WP_009874973.1	dimethylsulfoxide reductase subunit B	-
CYK57_RS09405	2006477..2007310	+	834	WP_009874972.1	dimethyl sulfoxide reductase anchor subunit	-
CYK57_RS09410	2007366..2007971	+	606	WP_009874971.1	Tat proofreading chaperone DmsD	-
CYK57_RS09415	2007975..2008484	+	510	WP_009874970.1	ferredoxin-type protein NapF	-
CYK57_RS09420	2008528..2008857	-	330	WP_005613259.1	helix-turn-helix domain-containing protein	Antitoxin
CYK57_RS09425	2008854..2010185	-	1332	WP_011848633.1	type II toxin-antitoxin system HipA family toxin	Toxin
CYK57_RS09430	2010517..2012208	-	1692	WP_042655118.1	AIPR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (164-371)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51131.07 Da
• Isoelectric Point: 5.0347

>T92648 WP_011848633.1 NZ_CP026009:c2010185-2008854 [Actinobacillus pleuropneumoniae]
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHADKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAMVGG
ATGAGGEAPKLLLKCQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNIISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNPQEFAGEYRFDKIADGLSDLIEPDILLRELR
MLATQLVDLKSRLMKRGVPKSILDFPAIGFDYLPEKLQRWGLV

Nucleotide

• Length: 1332 bp

>T92648 NZ_CP026009:c2010185-2008854 [Actinobacillus pleuropneumoniae]
ATGAGTGATATATCAGTCAAAAATAAAAAATTAACATTGCAGACCTATGTTGATAATCTATGGCGAGATATGGCGGAGCT
TTATTTCAATGCTCAGTATGAATTAGAGAGCATGGAATATTTAACGGACTATGCCGTCGATTTTTTTGGGCAAGCGAATG
CCAGATCCATATCAATTAATTATCCTGTAAATGTGTTTATTGATCATGCCGATAAGCTGATGACTACACTTGCCGATATT
ATTCCTGCCGGAGCGAGTCGGCGTTATTGGCTGGAAGCTCTTGATATCAAGCACCTATCTATTTCTCATCAAAATTACTT
ATTGCTAAAAAATGGCGCAATATCCCCTATCGGCAATGTCCGAGTTAAAGAGGCTGTGCCAGAAATACAAAGTGAGCGTT
ATTTTCCATTAAATGTGGTACAAAACAGGCAGAGTGATTTTTTAGAATATGCAAATCAGACAGGAGCTATGGTAGGCGGA
GCGACTGGGGCTGGGGGAGAAGCACCAAAGCTATTACTTAAATGCCAAGATAAACAAGTTTGGATTGATAATTTACAATT
AGGTCTAGATTGCGATACGGCTTATTTAGTGAAATATCCTCGTGGGAATTATTCAGAGTTGGACTGTGATATTTTAAGAG
CTGAATATCATTATTATCATGAGCTGCGTGCATTAGGGTTTTCAACTATAGATACTGATCTAATGAAATTAGAAGAGGGG
GAACGTTATCCGTCTTTATGGCTACCTAGATTCGATATGAAGTTCAAAGATGGAAAATGGGAGCGATATGCTATGGAATC
GGTTTATTCTATGTTACAAAAATATGGTGGAAATCTTGATCATGAGCAGACTATTCGCAACTTACTCAATATTATTTCAG
CTTCGCAATTTTCTAATGATTTTGATAACCGGCATTTTGTTATTGAATGGGTAAAGCGAGATTTGTTGAATATTGCTTTT
GGAAATAGTGATAATCATGGCAGAAATACTGCATTTTTACGTGATGATAATCGTATTTGGCTATCCCCTATCTATGATTT
TGCTCCGATGCGGGCAGATCCGGAAGGCATTATCAGAACGACCACTTGGGCTAAAAATGGAGATAACCCTCAAGAGTTCG
CCGGAGAATATCGCTTTGATAAAATAGCTGACGGTTTATCTGACCTTATTGAACCAGATATATTGTTAAGAGAATTAAGA
ATGCTTGCTACCCAATTAGTAGATTTAAAATCTAGACTTATGAAGCGAGGTGTTCCGAAAAGTATTTTAGATTTTCCCGC
CATTGGTTTTGATTACTTACCTGAGAAGTTACAACGTTGGGGGCTGGTATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12320.45 Da
• Isoelectric Point: 10.8292

>AT92648 WP_005613259.1 NZ_CP026009:c2008857-2008528 [Actinobacillus pleuropneumoniae]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp

>AT92648 NZ_CP026009:c2008857-2008528 [Actinobacillus pleuropneumoniae]
ATGACGATTCAACATAAAAATGCCTCACCGACGCGATCTAAAGTGAATGGCATTGAACGACAATTAATCCGTGAAACGAT
TATAGTACAGCTCTTAAAAGGTGAGATTAGTCAAGGACAAGCACTACGTCGATTACGGGTAGAAGCATTAGGAATAAACC
AGCAAGATTATCTAAAATTAGCGAAAGTTTCTCGGCAAACGCTTTCTAATATCGAAAATGATAAAGGAAACTATAGTATA
GAGACAATTAATCAGGTATTTAAACCGATGGGACTAAAGCTAGGTCTTATGCCGATCTCAAAAGACTTGATGGCTTCCTT
TCTTAAATAA

Structures

Toxin

• AlphaFold DB: A3N2X8

Antitoxin

• AlphaFold DB: A3N2X7