Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 890267..891102 Replicon chromosome
Accession NZ_CP025859
Organism Escherichia coli strain 504239

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag CXV92_RS04560 Protein ID WP_000854752.1
Coordinates 890725..891102 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag CXV92_RS04555 Protein ID WP_001278232.1
Coordinates 890267..890635 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV92_RS04520 887103..887558 + 456 WP_000581504.1 hypothetical protein -
CXV92_RS04525 887637..887870 + 234 WP_001119729.1 DUF905 family protein -
CXV92_RS04535 887970..888788 + 819 WP_001234620.1 DUF945 domain-containing protein -
CXV92_RS04540 888843..889328 + 486 WP_000849582.1 antirestriction protein -
CXV92_RS04545 889344..889820 + 477 WP_001186774.1 RadC family protein -
CXV92_RS04550 889883..890104 + 222 WP_000692318.1 DUF987 domain-containing protein -
CXV92_RS04555 890267..890635 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CXV92_RS04560 890725..891102 + 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
CXV92_RS04565 891099..891302 + 204 WP_000761705.1 hypothetical protein -
CXV92_RS04570 891315..891428 + 114 WP_001161660.1 DUF957 domain-containing protein -
CXV92_RS26405 892244..892615 + 372 WP_001295631.1 IS110 family transposase -
CXV92_RS04580 892774..893247 - 474 Protein_878 IS3 family transposase -
CXV92_RS04585 893337..894845 - 1509 WP_001474883.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T92188 WP_000854752.1 NZ_CP025859:890725-891102 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T92188 NZ_CP025859:890725-891102 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCCCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT92188 WP_001278232.1 NZ_CP025859:890267-890635 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT92188 NZ_CP025859:890267-890635 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References