Detailed information of TA system TA091909

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1276859..1277691
• Replicon: chromosome
• Accession: NZ_CP025753
• Organism: Escherichia coli strain CV839-06

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: S1PD64
• Locus tag: CV83906_RS07570
• Protein ID: WP_000854753.1
• Coordinates: 1276859..1277233 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: V0ULY5
• Locus tag: CV83906_RS07575
• Protein ID: WP_001315620.1
• Coordinates: 1277323..1277691 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV83906_RS07525	1272066..1273172	+	1107	WP_001299704.1	N-acetylneuraminate epimerase	-
CV83906_RS07530	1273237..1274217	+	981	WP_000991458.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
CV83906_RS07535	1274225..1274875	-	651	WP_001037966.1	HNH endonuclease	-
CV83906_RS26825	1275928..1276080	-	153	WP_001280484.1	hypothetical protein	-
CV83906_RS07560	1276165..1276362	-	198	WP_000839282.1	DUF957 domain-containing protein	-
CV83906_RS07565	1276374..1276862	-	489	WP_000777548.1	hypothetical protein	-
CV83906_RS07570	1276859..1277233	-	375	WP_000854753.1	TA system toxin CbtA family protein	Toxin
CV83906_RS07575	1277323..1277691	-	369	WP_001315620.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CV83906_RS07580	1277854..1278075	-	222	WP_000692345.1	DUF987 domain-containing protein	-
CV83906_RS07585	1278138..1278614	-	477	WP_001186774.1	RadC family protein	-
CV83906_RS07590	1278630..1279115	-	486	WP_000849588.1	antirestriction protein	-
CV83906_RS07595	1279170..1279988	-	819	WP_001234620.1	DUF945 domain-containing protein	-
CV83906_RS07605	1280088..1280321	-	234	WP_001119729.1	DUF905 family protein	-
CV83906_RS07610	1280400..1280855	-	456	WP_000581504.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14005.00 Da
• Isoelectric Point: 8.2905

>T91909 WP_000854753.1 NZ_CP025753:c1277233-1276859 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Nucleotide

• Length: 375 bp

>T91909 NZ_CP025753:c1277233-1276859 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13474.20 Da
• Isoelectric Point: 6.2050

>AT91909 WP_001315620.1 NZ_CP025753:c1277691-1277323 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT91909 NZ_CP025753:c1277691-1277323 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7U9LVU0

Antitoxin

• AlphaFold DB: V0ULY5