Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1944786..1945398 Replicon chromosome
Accession NZ_CP025682
Organism Azoarcus pumilus strain SY39

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C0099_RS09355 Protein ID WP_102248455.1
Coordinates 1945090..1945398 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C0099_RS09350 Protein ID WP_102247190.1
Coordinates 1944786..1945097 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0099_RS15860 1940242..1940475 + 234 WP_123785235.1 hypothetical protein -
C0099_RS09330 1940557..1941303 + 747 WP_102247186.1 diguanylate cyclase -
C0099_RS09335 1941319..1941753 - 435 WP_123785236.1 hypothetical protein -
C0099_RS09340 1941867..1943837 - 1971 WP_102247188.1 ATP-dependent DNA helicase -
C0099_RS09345 1944595..1944789 + 195 WP_199797589.1 type II toxin-antitoxin system HicB family antitoxin -
C0099_RS09350 1944786..1945097 - 312 WP_102247190.1 putative addiction module antidote protein Antitoxin
C0099_RS09355 1945090..1945398 - 309 WP_102248455.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0099_RS09360 1945466..1946557 - 1092 WP_102247191.1 cell division protein ZapE -
C0099_RS09365 1946596..1948023 - 1428 WP_102247192.1 dihydrolipoyl dehydrogenase -
C0099_RS09370 1948093..1949331 - 1239 WP_102247193.1 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(8-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11529.22 Da        Isoelectric Point: 10.3339

>T91708 WP_102248455.1 NZ_CP025682:c1945398-1945090 [Azoarcus pumilus]
VYQLKQTTVFGKWESSLRDKRARALIASRLDRLAYFGHAGDTRVVGDGISELRIHYGPGYRIYFEMRGSLLILLLCGGDK
GSQQRDIKAAKKLAREWGAQND

Download         Length: 309 bp

>T91708 NZ_CP025682:c1945398-1945090 [Azoarcus pumilus]
GTGTATCAACTCAAGCAAACAACGGTCTTCGGAAAGTGGGAGTCCAGCCTGCGTGACAAACGTGCGCGGGCTTTGATCGC
GTCTCGTCTCGATCGTCTCGCCTACTTTGGTCATGCCGGTGATACGAGGGTTGTCGGGGACGGGATCAGCGAATTGCGGA
TTCACTACGGCCCCGGTTATCGAATCTATTTCGAAATGCGCGGTAGTTTGCTGATTCTGCTTCTTTGCGGCGGCGACAAG
GGCTCGCAGCAGCGGGATATCAAGGCGGCAAAGAAGCTGGCACGAGAATGGGGTGCGCAGAATGATTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11061.54 Da        Isoelectric Point: 4.3440

>AT91708 WP_102247190.1 NZ_CP025682:c1945097-1944786 [Azoarcus pumilus]
MIDEPTTYDPAVALVDKESIALFMAEAFETGDAGYIAHALGVVARARGMSEIARETGLSREQLYRSFSDDGNPTLRTTLA
VMKALGIEVTAKPQGITPNICEN

Download         Length: 312 bp

>AT91708 NZ_CP025682:c1945097-1944786 [Azoarcus pumilus]
ATGATTGATGAACCGACGACCTATGATCCCGCAGTTGCGCTGGTGGACAAGGAGTCGATTGCGCTGTTCATGGCCGAAGC
CTTCGAGACGGGAGACGCCGGCTATATCGCCCATGCGCTCGGCGTCGTCGCCCGCGCCAGGGGCATGAGCGAAATCGCCA
GGGAGACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCGTTCAGCGACGACGGCAACCCGACGCTGAGAACAACGTTGGCG
GTAATGAAAGCATTGGGTATCGAAGTGACCGCGAAACCGCAGGGCATTACGCCGAATATCTGCGAAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References