Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1838047..1838693 Replicon chromosome
Accession NZ_CP025682
Organism Azoarcus pumilus strain SY39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C0099_RS08850 Protein ID WP_102247101.1
Coordinates 1838047..1838454 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C0099_RS08855 Protein ID WP_102247102.1
Coordinates 1838454..1838693 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0099_RS08820 1833593..1835632 + 2040 WP_102247096.1 hypothetical protein -
C0099_RS08825 1835747..1836106 + 360 WP_102247097.1 nuclear transport factor 2 family protein -
C0099_RS08830 1836090..1836413 - 324 WP_199797587.1 type II toxin-antitoxin system RelE/ParE family toxin -
C0099_RS08835 1836410..1836649 - 240 WP_102247098.1 addiction module protein -
C0099_RS08840 1836711..1837436 - 726 WP_102247099.1 ABC transporter ATP-binding protein -
C0099_RS08845 1837420..1838028 + 609 WP_102247100.1 arylesterase -
C0099_RS08850 1838047..1838454 - 408 WP_102247101.1 type II toxin-antitoxin system VapC family toxin Toxin
C0099_RS08855 1838454..1838693 - 240 WP_102247102.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C0099_RS08860 1838821..1839867 + 1047 WP_102247103.1 tRNA 2-selenouridine(34) synthase MnmH -
C0099_RS08865 1839878..1840432 - 555 WP_102247104.1 class I SAM-dependent methyltransferase -
C0099_RS08870 1840429..1841889 - 1461 WP_102247105.1 NAD-dependent succinate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-126)

Antitoxin

SpoVT-AbrB domain

(10-46)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14994.91 Da        Isoelectric Point: 4.8146

>T91707 WP_102247101.1 NZ_CP025682:c1838454-1838047 [Azoarcus pumilus]
MAASRYLLDTNILSELIRDPQGPVTQRIAALDDGAICTSIVVAGELRYGAARRGSPTLTGRVEQLLEHVEVLALDEAADR
HYAEIRNDLEREGRVIGANDLWIAAHARSLDHILVTRNLREFERVPGLQIESWGD

Download         Length: 408 bp

>T91707 NZ_CP025682:c1838454-1838047 [Azoarcus pumilus]
ATGGCTGCATCCCGCTATCTTCTCGACACCAACATCCTGTCCGAACTGATCCGCGATCCGCAGGGGCCGGTGACGCAACG
CATCGCGGCGCTCGACGATGGGGCCATCTGTACCAGCATCGTGGTGGCCGGGGAATTGCGTTACGGCGCGGCGCGACGGG
GCTCGCCGACCTTGACGGGCCGCGTCGAACAACTGCTGGAGCATGTCGAAGTGCTGGCGCTCGACGAGGCAGCGGATCGA
CATTACGCCGAAATTCGCAACGATCTGGAGCGGGAGGGGCGGGTGATCGGCGCCAATGACTTATGGATCGCTGCGCACGC
ACGCTCACTCGACCACATTCTCGTTACCCGAAACCTGCGCGAATTCGAGCGCGTGCCCGGCCTGCAGATCGAAAGCTGGG
GCGATTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8900.23 Da        Isoelectric Point: 4.7906

>AT91707 WP_102247102.1 NZ_CP025682:c1838693-1838454 [Azoarcus pumilus]
MTQQRHVSLFRNGRNQAVRIPREFEMEGTEAIMRKEGDRLIIEPAPPRVGLLGLLAGWAPMDEALPEVADHPPPVEDVF

Download         Length: 240 bp

>AT91707 NZ_CP025682:c1838693-1838454 [Azoarcus pumilus]
ATGACGCAACAACGCCATGTTTCGCTGTTTCGCAATGGTCGCAATCAGGCCGTGCGCATTCCGCGCGAGTTCGAGATGGA
GGGCACTGAAGCGATCATGCGCAAGGAAGGCGATCGGCTGATCATCGAGCCGGCGCCCCCGCGCGTGGGGCTCCTGGGAT
TGCTGGCCGGCTGGGCGCCGATGGATGAAGCCCTGCCGGAGGTGGCCGACCACCCGCCGCCCGTCGAGGACGTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References