Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2865354..2866189 Replicon chromosome
Accession NZ_CP025676
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L6W3P3
Locus tag C0R48_RS14805 Protein ID WP_075362639.1
Coordinates 2865354..2865731 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L6W4Z7
Locus tag C0R48_RS14810 Protein ID WP_070749977.1
Coordinates 2865821..2866189 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS14765 2860354..2860836 - 483 WP_010343298.1 DUF1097 domain-containing protein -
C0R48_RS14770 2860938..2861492 - 555 WP_054410851.1 molecular chaperone YcdY -
C0R48_RS14775 2861516..2862253 - 738 WP_000283677.1 phosphatase -
C0R48_RS14780 2862325..2863263 - 939 WP_054410854.1 glyoxylate/hydroxypyruvate reductase GhrA -
C0R48_RS14790 2863733..2864575 - 843 WP_075362638.1 DUF4942 domain-containing protein -
C0R48_RS14795 2864660..2864857 - 198 WP_072643848.1 DUF957 domain-containing protein -
C0R48_RS14800 2864869..2865357 - 489 WP_039022338.1 hypothetical protein -
C0R48_RS14805 2865354..2865731 - 378 WP_075362639.1 TA system toxin CbtA family protein Toxin
C0R48_RS14810 2865821..2866189 - 369 WP_070749977.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C0R48_RS14815 2866239..2866883 - 645 WP_039025881.1 hypothetical protein -
C0R48_RS14820 2866898..2867119 - 222 WP_000692312.1 DUF987 domain-containing protein -
C0R48_RS14825 2867188..2867664 - 477 WP_001186770.1 RadC family protein -
C0R48_RS14830 2867680..2868153 - 474 WP_075362640.1 antirestriction protein -
C0R48_RS14840 2868495..2869313 - 819 WP_075362641.1 DUF945 domain-containing protein -
C0R48_RS27280 2869407..2869585 + 179 Protein_2746 hypothetical protein -
C0R48_RS14850 2869724..2870137 - 414 WP_000789536.1 hypothetical protein -
C0R48_RS14855 2870407..2870946 - 540 WP_001104026.1 DUF4339 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14112.20 Da        Isoelectric Point: 8.2962

>T91671 WP_075362639.1 NZ_CP025676:c2865731-2865354 [Escherichia albertii]
MKTLPDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T91671 NZ_CP025676:c2865731-2865354 [Escherichia albertii]
ATGAAAACATTACCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13860.63 Da        Isoelectric Point: 6.3177

>AT91671 WP_070749977.1 NZ_CP025676:c2866189-2865821 [Escherichia albertii]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQVFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT91671 NZ_CP025676:c2866189-2865821 [Escherichia albertii]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATTTGGACCAGGTCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6W3P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6W4Z7

References