Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707620..3708294 Replicon chromosome
Accession NZ_CP025602
Organism Mycobacterium tuberculosis strain GG-109-10

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag C0096_RS18210 Protein ID WP_003417282.1
Coordinates 3707620..3708048 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag C0096_RS18215 Protein ID WP_003417286.1
Coordinates 3708052..3708294 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0096_RS18185 3703442..3703843 - 402 WP_003417264.1 cytidine deaminase -
C0096_RS18190 3703984..3704418 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
C0096_RS18195 3704415..3704849 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
C0096_RS18200 3704978..3706750 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
C0096_RS18205 3706750..3707541 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
C0096_RS18210 3707620..3708048 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
C0096_RS18215 3708052..3708294 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
C0096_RS18220 3708416..3709030 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
C0096_RS18225 3709027..3709692 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
C0096_RS18230 3709693..3710226 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
C0096_RS18235 3710223..3710312 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
C0096_RS18240 3710411..3711672 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T91233 WP_003417282.1 NZ_CP025602:c3708048-3707620 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T91233 NZ_CP025602:c3708048-3707620 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT91233 WP_003417286.1 NZ_CP025602:c3708294-3708052 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT91233 NZ_CP025602:c3708294-3708052 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References