Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976591..2977239 Replicon chromosome
Accession NZ_CP025598
Organism Mycobacterium tuberculosis strain GG-37-11

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag C0084_RS14565 Protein ID WP_003899414.1
Coordinates 2976591..2976914 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag C0084_RS14570 Protein ID WP_003899415.1
Coordinates 2976994..2977239 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0084_RS14545 2972157..2973418 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
C0084_RS14550 2973792..2975231 - 1440 WP_003899411.1 phage major capsid protein -
C0084_RS14555 2975239..2975772 - 534 WP_003899412.1 HK97 family phage prohead protease -
C0084_RS14560 2975933..2976424 - 492 WP_003900541.1 phage terminase small subunit P27 family -
C0084_RS14565 2976591..2976914 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
C0084_RS14570 2976994..2977239 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
C0084_RS14575 2977236..2978663 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
C0084_RS14580 2978665..2979057 - 393 WP_003899417.1 DUF2742 domain-containing protein -
C0084_RS14585 2979054..2979314 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
C0084_RS14590 2979331..2979693 - 363 WP_003900543.1 hypothetical protein -
C0084_RS14595 2979696..2980823 - 1128 WP_003899420.1 site-specific integrase -
C0084_RS14600 2980968..2981195 - 228 WP_003899421.1 hypothetical protein -
C0084_RS14605 2981192..2981581 - 390 WP_003899422.1 hypothetical protein -
C0084_RS14610 2981487..2981759 + 273 WP_003900544.1 hypothetical protein -
C0084_RS14615 2981858..2982091 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970548..2980823 10275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T90980 WP_003899414.1 NZ_CP025598:c2976914-2976591 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T90980 NZ_CP025598:c2976914-2976591 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT90980 WP_003899415.1 NZ_CP025598:c2977239-2976994 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT90980 NZ_CP025598:c2977239-2976994 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References