Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1384233..1384921 Replicon chromosome
Accession NZ_CP025597
Organism Mycobacterium tuberculosis strain GG-36-11

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag C0086_RS06815 Protein ID WP_003406304.1
Coordinates 1384490..1384921 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag C0086_RS06810 Protein ID WP_003406302.1
Coordinates 1384233..1384493 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0086_RS06790 1379810..1380634 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
C0086_RS06795 1380639..1381820 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
C0086_RS06800 1381897..1382997 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
C0086_RS06805 1383168..1384157 + 990 WP_003406301.1 malate dehydrogenase -
C0086_RS06810 1384233..1384493 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
C0086_RS06815 1384490..1384921 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
C0086_RS06820 1384944..1386632 - 1689 WP_003910308.1 PE family protein -
C0086_RS06830 1386812..1387672 + 861 WP_003900301.1 hypothetical protein -
C0086_RS06835 1387753..1388583 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
C0086_RS06840 1388640..1388933 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
C0086_RS06845 1388930..1389199 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T90894 WP_003406304.1 NZ_CP025597:1384490-1384921 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T90894 NZ_CP025597:1384490-1384921 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT90894 WP_003406302.1 NZ_CP025597:1384233-1384493 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT90894 NZ_CP025597:1384233-1384493 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References