Detailed information of TA system TA090293

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3999206..3999428
• Replicon: chromosome
• Accession: NZ_CP025401
• Organism: Escherichia coli strain MS8345

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: MS8345_RS29865
• Protein ID: WP_001295224.1
• Coordinates: 3999206..3999313 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3999362..3999428 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS8345_RS20915	3994741..3994929	-	189	WP_001063314.1	YhjR family protein	-
MS8345_RS20920	3995202..3996773	+	1572	WP_001204957.1	cellulose biosynthesis protein BcsE	-
MS8345_RS20925	3996770..3996961	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
MS8345_RS20930	3996958..3998637	+	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
MS8345_RS20935	3998723..3998830	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
MS8345_RS29865	3999206..3999313	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3999362..3999428	+	67	-	-	Antitoxin
MS8345_RS20950	3999688..3999795	-	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	-
MS8345_RS20965	4000271..4001542	+	1272	WP_001332306.1	amino acid permease	-
MS8345_RS20970	4001572..4002576	-	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-
MS8345_RS20975	4002573..4003556	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T90293 WP_001295224.1 NZ_CP025401:c3999313-3999206 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T90293 NZ_CP025401:c3999313-3999206 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT90293 NZ_CP025401:3999362-3999428 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin