Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3998723..3998945 Replicon chromosome
Accession NZ_CP025401
Organism Escherichia coli strain MS8345

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag MS8345_RS20935 Protein ID WP_001295224.1
Coordinates 3998723..3998830 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3998887..3998945 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS8345_RS20910 3993977..3994729 - 753 WP_000279545.1 cellulose biosynthesis protein BcsQ -
MS8345_RS20915 3994741..3994929 - 189 WP_001063314.1 YhjR family protein -
MS8345_RS20920 3995202..3996773 + 1572 WP_001204957.1 cellulose biosynthesis protein BcsE -
MS8345_RS20925 3996770..3996961 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
MS8345_RS20930 3996958..3998637 + 1680 WP_000191567.1 cellulose biosynthesis protein BcsG -
MS8345_RS20935 3998723..3998830 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 3998887..3998945 + 59 - - Antitoxin
MS8345_RS29865 3999206..3999313 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
MS8345_RS20950 3999688..3999795 - 108 WP_000170745.1 type I toxin-antitoxin system toxin Ldr family protein -
MS8345_RS20965 4000271..4001542 + 1272 WP_001332306.1 amino acid permease -
MS8345_RS20970 4001572..4002576 - 1005 WP_000103579.1 dipeptide ABC transporter ATP-binding subunit DppF -
MS8345_RS20975 4002573..4003556 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T90291 WP_001295224.1 NZ_CP025401:c3998830-3998723 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T90291 NZ_CP025401:c3998830-3998723 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 59 bp

>AT90291 NZ_CP025401:3998887-3998945 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References