Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15435..15693 Replicon chromosome
Accession NZ_CP025328
Organism Escherichia coli strain ExPEC XM

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag CXG97_RS00075 Protein ID WP_000809168.1
Coordinates 15435..15587 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15636..15693 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXG97_RS00055 10680..11393 - 714 WP_001102393.1 acidic protein MsyB -
CXG97_RS00060 11419..11823 - 405 WP_000843687.1 DUF2541 family protein -
CXG97_RS00065 12195..14111 + 1917 WP_000516135.1 molecular chaperone DnaK -
CXG97_RS00070 14200..15330 + 1131 WP_001118464.1 molecular chaperone DnaJ -
CXG97_RS00075 15435..15587 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15636..15693 + 58 - - Antitoxin
CXG97_RS00080 16199..16960 + 762 WP_001274823.1 hypothetical protein -
CXG97_RS00085 16980..18473 + 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
CXG97_RS00090 18602..19861 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T90097 WP_000809168.1 NZ_CP025328:c15587-15435 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T90097 NZ_CP025328:c15587-15435 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT90097 NZ_CP025328:15636-15693 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References