Detailed information of TA system TA090074

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4633447..4634245
• Replicon: chromosome
• Accession: NZ_CP025317
• Organism: Escherichia albertii strain 1551-2

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CXP54_RS23595
• Protein ID: WP_103054251.1
• Coordinates: 4633868..4634245 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CXP54_RS23590
• Protein ID: WP_103054250.1
• Coordinates: 4633447..4633821 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXP54_RS23545	4629202..4629744	+	543	WP_103054246.1	hypothetical protein	-
CXP54_RS23550	4630105..4630587	+	483	WP_103054247.1	hypothetical protein	-
CXP54_RS23565	4630956..4631741	+	786	WP_103054248.1	DUF945 domain-containing protein	-
CXP54_RS23570	4631777..4632022	+	246	WP_089639732.1	antirestriction protein	-
CXP54_RS23575	4632116..4632589	+	474	WP_050008752.1	antirestriction protein	-
CXP54_RS23580	4632605..4633081	+	477	WP_158649901.1	RadC family protein	-
CXP54_RS23585	4633150..4633371	+	222	WP_103054249.1	DUF987 domain-containing protein	-
CXP54_RS23590	4633447..4633821	+	375	WP_103054250.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CXP54_RS23595	4633868..4634245	+	378	WP_103054251.1	TA system toxin CbtA family protein	Toxin
CXP54_RS23600	4634242..4634730	+	489	WP_103054252.1	hypothetical protein	-
CXP54_RS23605	4634748..4634939	+	192	WP_103054253.1	DUF957 domain-containing protein	-
CXP54_RS23615	4635516..4636013	+	498	Protein_4337	integrase arm-type DNA-binding domain-containing protein	-
CXP54_RS23620	4635982..4636604	+	623	Protein_4338	transposase	-
CXP54_RS23625	4636992..4637990	+	999	WP_059214712.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14097.06 Da
• Isoelectric Point: 7.8050

>T90074 WP_103054251.1 NZ_CP025317:4633868-4634245 [Escherichia albertii]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR

Nucleotide

• Length: 378 bp

>T90074 NZ_CP025317:4633868-4634245 [Escherichia albertii]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGCACGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13814.61 Da
• Isoelectric Point: 6.3141

>AT90074 WP_103054250.1 NZ_CP025317:4633447-4633821 [Escherichia albertii]
MPDTLHETNHPDNNNNSPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLEQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT90074 NZ_CP025317:4633447-4633821 [Escherichia albertii]
ATGCCAGACACGCTCCATGAGACAAATCACCCCGACAACAATAACAACAGCCCCTGGTGGGGACTCCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCGGATGCGTACCACCTGGAGCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA